Article date: July 1982
By: DB Rowlands, DR Glover, TJ Stallard, WA Littler, in Volume 14, Issue 1, pages 89-95
1 Ten untreated hypertensive patients underwent 24 h continuous intra‐ arterial ambulatory monitoring of blood pressure (BP) and M‐mode echocardiography. 2 They were treated with once‐daily timolol and followed up at 2, 4, 8 and 12 weeks when dosage was titrated against BP control (indirect measurement) and degree of beta‐adrenoceptor antagonism (submaximal bicycle ergometry and sub‐lingual GTN). 3 Sixteen weeks after commencing therapy, nine patients underwent repeat continuous ambulatory monitoring of BP and M‐mode echocardiography. 4 Casual BP was significantly reduced during the follow‐up period at 2, 4, 8 and 12 weeks. 5 A reduction of BP was seen throughout the 24 h although this did not achieve statistical significance when sympathetic activity was low. 6 Echocardiographic measurement of left ventricular mass was significantly reduced after 16 weeks treatment.
DOI: 10.1111/j.1365-2125.1982.tb04939.x
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