Article date: April 1982
By: R Zaman, MJ Kendall, PI Biggs, in Volume 13, Issue 4, pages 507-512
1 The effect of acebutolol, a relatively selective beta‐adrenoceptor blocking drug and propranolol, a non‐selective one, on the hypoglycaemic action of glibenclamide after an oral glucose load has been investigated in a group of maturity‐onset diabetic patients. 2 Glibenclamide significantly reduced the blood glucose levels and both acebutolol and propranolol, at therapeutic doses, were found to modify this action significantly. 3 The effect of acebutolol was slightly less than that of propranolol. The difference was not statistically significant. 4 The modes of action of sulphonylureas are reviewed and it is suggested that beta‐adrenoceptor blockers may modify their effect on insulin release. This appears to be a drug interaction rather than an effect of beta‐adrenoceptor blockade on glucose tolerance.
DOI: 10.1111/j.1365-2125.1982.tb01412.x
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