Article date: November 1981
By: PG Blain, JC Mucklow, CJ Bacon, MD Rawlins, in Volume 12, Issue 5, pages 659-661
1 Apparent Vmax and Km for phenytoin were estimated in 40 children (aged 8–33 months) and 21 adults (aged 18–66 years). 2 The derived values of Vmax and Km were used to predict the plasma and salivary concentrations of phenytoin following a change in dose. There was a highly significant correlation between observed and predicted steady‐ state concentration in both children and adults (P less than 0.001). 3 The apparent Km was similar in children (7.5 +/‐ 1.2 mg/l) and adults (9.4 +/‐ 2.3 mg/l). 4 Vmax differed significantly (P less than 0.001) between children (20.4 +/‐ 2.1 mg kg‐1 day‐1) and adults (8.7 +/‐ 0.7 mg kg‐1 day‐1). 5 After correction for differences in the ratio of liver weight to body weight in children and adults, Vmax was similar in the two groups.
DOI: 10.1111/j.1365-2125.1981.tb01285.x
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