PROTACs in Drug Discovery - Training Workshop

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This training workshop will introduce and explore the role of proteolysis targeting chimeras (PROTACs) as bifunctional molecule protein degraders. This will include their application in drug discovery and why they offer a new approach in targeting some diseases over conventional small molecule drugs.

The workshop is part of the New Modalities in pHarmacology and Drug Discovery joint meeting from the British Pharmacological Society and ELRIG UK.

This training is aimed at early career researchers, pre-clinical and clinical scientists/professional wanted to learn more about these new drug modalities within drug discovery.

Join us for an introductory level expert led series of discussions and small group problem-based learning sessions on:

1. The biophysics of PROTACs and understanding the cooperativity of PROTAC molecules.
2. The function of turning a protein binder into a protein degrader. Including PROTAC selectivity and SAR.
3. An understanding of the safety of PROTACs and how this can be profiled and optimised for development.
4. The current developments in PROTAC design and new ligases for the future.

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