Article date: September 2017
By: Corine Jong, Stefan Sanders, Geert‐Jan Creemers, Artur M. Burylo, Margot Taks, Jan H.M. Schellens, Maarten J. Deenen in Volume 83, Issue 9, pages 2120-2122
In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low‐doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c.616–367C>T). As COMT polymorphism has been associated with cisplatin‐induced ototoxicity, its effect on nephrotoxicity of cisplatin should be the subject of further investigation.
DOI: 10.1111/bcp.13309
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