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Pharmacology Research & Perspectives

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Leucine‐rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes

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Article date: June 2019

Authors: Daniela Mercatelli, Paolo Bolognesi, Martina Frassineti, Clarissa A. Pisanò, Francesco Longo, Derya R. Shimshek, Michele Morari

Health professionals’ and researchers’ opinions on conducting clinical deprescribing trials

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Article date: June 2019

Authors: Alexander J. Clough, Sarah N. Hilmer, Lisa Kouladjian‐O'Donnell, Sharon L. Naismith, Danijela Gnjidic

Application of ultrasound‐guided cholecystocentesis to the evaluation of the metabolite profiling in bile of dogs and cynomolgus monkeys

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Article date: June 2019

Authors: Elizabeth A. Dierks, Chiuwa E. Luk, Hong Cai, Jamus MacGuire, Maxine Fox, James Smalley, R. Marc Fancher, Evan Janovitz, Kimberly Foster, Qin Sun

Preclinical characterization of AMPA receptor potentiator TAK‐137 as a therapeutic drug for schizophrenia

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Article date: June 2019

Authors: Maiko Tanaka, Akiyoshi Kunugi, Atsushi Suzuki, Noriko Suzuki, Motohisa Suzuki, Haruhide Kimura

Histidine‐rich glycoprotein augments natural killer cell function by modulating PD‐1 expression via CLEC‐1B

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Article date: June 2019

Authors: Yoshito Nishimura, Hidenori Wake, Kiyoshi Teshigawara, Dengli Wang, Masakiyo Sakaguchi, Fumio Otsuka, Masahiro Nishibori

The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats

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Article date: June 2019

Authors: Andrew S. Kucey, Thomas J. Velenosi, Nicholas C. Tonial, Alvin Tieu, Adrien A. E. RaoPeters, Brad L. Urquhart

Depressive disorders: Treatment failures and poor prognosis over the last 50 years

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Article date: June 2019

Authors: Thomas P. Blackburn

Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling

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Article date: June 2019

Authors: Marthe F. Fjelldal, Thibaud Freyd, Linn M. Evenseth, Ingebrigt Sylte, Avi Ring, Ragnhild E. Paulsen

Prescribing trend in cardiovascular patients at Ethiopian university hospital: The number of medications and implication on the clinical improvement

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Article date: June 2019

Authors: Yonas G. Tefera, Tamrat B. Abebe, Abebe B. Mekuria, Misganaw S. Kelkay, Tadesse M. Abegaz

Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist

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Article date: June 2019

Authors: Tyler W. McCullock, Paul J. Kammermeier