Pharmacology Research & Perspectives

Evaluation of morphine‐like effects of the mixed mu/delta agonist morphine‐6‐O‐sulfate in rats: Drug discrimination and physical dependence

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Article date: July 2018

Authors: Jai Shankar K. Yadlapalli, Shoban Babu Bommagani, Ryan D. Mahelona, Anqi Wan, Brenda M. Gannon, Narsimha R. Penthala, Maxim Dobretsov, Peter A. Crooks, William E. Fantegrossi

Potential role for histone deacetylation in chronic diazepam‐induced downregulation of α1‐GABA_A receptor subunit expression

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Article date: July 2018

Authors: James Auta, Eleonora Gatta, John M. Davis, Subhash C. Pandey, Alessandro Guidotti

The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects

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Article date: July 2018

Authors: Mark Johnson, Roxanne C. Jewell, Amanda Peppercorn, Elizabeth Gould, Jianfeng Xu, Yu Lou, Matthew Davies, Sandra Baldwin, Allan R. Tenorio, Matthew Burke, Jerry Jeffrey, Brian A. Johns

Drug conjugates—an emerging approach to treat breast cancer

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Article date: July 2018

Authors: Mahmud Hasan, Rehana K. Leak, Robert E. Stratford, Darius P. Zlotos, Paula A. Witt‐Enderby

The G protein–coupled estrogen receptor agonist, G‐1, attenuates BK channel activation in cerebral arterial smooth muscle cells

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Article date: July 2018

Authors: Kirk W. Evanson, Jacob A. Goldsmith, Payal Ghosh, Michael D. Delp

Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype

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Article date: July 2018

Authors: Pernilla Haage, Robert Kronstrand, Martin Josefsson, Simona Calistri, Ron H. N. Schaik, Henrik Green, Fredrik C. Kugelberg

Issue Information

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Article date: July 2018

Pharmacokinetics, safety, and tolerability of the 2‐ and 3‐direct‐acting antiviral combination of AL‐335, odalasvir, and simeprevir in healthy subjects

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Article date: June 2018

Authors: Thomas N. Kakuda, Matthew W. McClure, Christopher Westland, Jennifer Vuong, Marie‐Claude Homery, Gwendoline Poizat, Laure Viguerie, Caroline Denot, Alain Patat, Qingling Zhang, James Hui, David Apelian, David B. Smith, Sushmita M. Chanda, John Fry

Pharmacokinetics and pharmacodynamics of the cytolytic anti‐CD38 human monoclonal antibody TAK‐079 in monkey – model assisted preparation for the first in human trial

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Article date: June 2018

Authors: Stefan Roepcke, Nele Plock, Josh Yuan, Eric R. Fedyk, Gezim Lahu, Lin Zhao, Glennda Smithson

Effect of a mitochondrial‐targeted coenzyme Q analog on pancreatic β‐cell function and energetics in high fat fed obese mice

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Article date: June 2018

Authors: Yumi Imai, Brian D. Fink, Joseph A. Promes, Chaitanya A. Kulkarni, Robert J. Kerns, William I. Sivitz