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Pharmacology Research & Perspectives

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The role of loops B and C in determining the potentiation of GABAA receptors by midazolam

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Article date: December 2018

Authors: Olivia A. Moody, Andrew Jenkins

Effects of cardiopulmonary bypass on the disposition of cefazolin in patients undergoing cardiothoracic surgery

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Article date: December 2018

Authors: Mizuho Asada, Masashi Nagata, Tomohiro Mizuno, Tokujiro Uchida, Naoki Kurashima, Hiromitsu Takahashi, Koshi Makita, Hirokuni Arai, Hirotoshi Echizen, Masato Yasuhara

Nonclinical safety assessment of a human interleukin‐22FC IG fusion protein demonstrates in vitro to in vivo and cross‐species translatability

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Article date: December 2018

Authors: Donna W. Lee, Shelly Zhong, Rama Pai, Julie Rae, Siddharth Sukumaran, Eric G. Stefanich, Jeff Lutman, Estelle Doudement, Xiaoting Wang, Brandon Harder, Annemarie Lekkerkerker, Ann Herman, Wenjun Ouyang, Dimitry M. Danilenko

Cellular density‐dependent increases in HIF‐1α compete with c‐Myc to down‐regulate human EP4 receptor promoter activity through Sp‐1‐binding region

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Article date: December 2018

Authors: Naofumi Seira, Kazuyuki Yamagata, Keijo Fukushima, Yumi Araki, Naoki Kurata, Naoki Yanagisawa, Masato Mashimo, Hiroyuki Nakamura, John W. Regan, Toshihiko Murayama, Hiromichi Fujino

Natural language processing‐based assessment of consistency in summaries of product characteristics of generic antimicrobials

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Article date: December 2018

Authors: Rumiko Shimazawa, Yoshinobu Kano, Masayuki Ikeda

Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model

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Article date: December 2018

Authors: Vishnu Chintalgattu, Joanne Greenberg, Shivani Singh, Venice Chiueh, Amy Gilbert, Jason W. O'Neill, Stephen Smith, Simon Jackson, Aarif Y. Khakoo, TaeWeon Lee

14,15‐epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells

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Article date: October 2018

Authors: Ami Oguro, Takumi Inoue, Suguru N. Kudoh, Susumu Imaoka

Patterns of adverse drug reaction signals in NAFDAC pharmacovigilance activities from January to June 2015: safety of drug use in Nigeria

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Article date: October 2018

Authors: Olufunsho Awodele, Rebecca Aliu, Ibrahim Ali, Yetunde Oni, Christianah Mojisola Adeyeye

Small‐Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models

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Article date: October 2018

Authors: Catherine M. Sampson, James M. Kasper, Daniel E. Felsing, Sweta R. Raval, Na Ye, Pingyuan Wang, Igor Patrikeev, Erik Rytting, Jia Zhou, John A. Allen, Jonathan D. Hommel