This website uses cookies to improve your experience. Learn more about cookies and how to manage them.

Pharmacology Research & Perspectives

Filter

Phase I study of PF‐04895162, a Kv7 channel inhibitor, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Pages: n/a-n/a

Article date: February 2019

Authors: Michael D. Aleo, Jiri Aubrecht, Paul D. Bonin, Deborah A. Burt, Jennifer Colangelo, Lina Luo, Shelli Schomaker, Rachel Swiss, Simon Kirby, Greg C. Rigdon, Pinky Dua

Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Pages: n/a-n/a

Article date: February 2019

Authors: Dana C. Walters, Erwin E. W. Jansen, Garrett R. Ainslie, Gajja S. Salomons, Madalyn N. Brown, Michelle A. Schmidt, Jean‐Baptiste Roullet, K. M. Gibson

Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

Pages: n/a-n/a

Article date: February 2019

Authors: Lien Wang, Grace Lee, Amy Shih, Chester Kuei, Diane Nepomuceno, Michelle Wennerholm, Frances Fan, Jiejun Wu, Pascal Bonaventure, Timothy W. Lovenberg, Changlu Liu

Diazepam is not a direct allosteric modulator of α1‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4

Pages: n/a-n/a

Article date: February 2019

Authors: Lisa M. Williams, Xiaoji He, Tasneem M. Vaid, Alaa Abdul‐Ridha, Alice R. Whitehead, Paul R. Gooley, Ross A.D. Bathgate, Spencer J. Williams, Daniel J. Scott

Treatment with new organic nitrites in pulmonary hypertension of acute experimental pulmonary embolism

Pages: n/a-n/a

Article date: February 2019

Authors: Kristofer F. Nilsson, Lars E. Gustafsson

Development and validation of PART (Pharmacotherapy Assessment in Renal Transplant Patients) criteria to assess drug‐related problems in an outpatient renal transplant population: A cross‐sectional study

Pages: n/a-n/a

Article date: February 2019

Authors: Layal El Raichani, Qian Du, Alexandre Mathieu, Sabrina Almassy, Lyne Lalonde, Djamal Berbiche, Elisabeth Gélinas‐Lemay, Nathalie Boudreau, Héloïse Cardinal

Combined antitumoral effects of pretubulysin and methotrexate

Pages: n/a-n/a

Article date: February 2019

Authors: Sarah Kern, Ines Truebenbach, Miriam Höhn, Jan Gorges, Uli Kazmaier, Stefan Zahler, Angelika M. Vollmar, Ernst Wagner

pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study

Pages: n/a-n/a

Article date: February 2019

Authors: Angélique Stéphanou, Annabelle Ballesta

Frequency and predictors of the potential overprescribing of antidepressants in elderly residents of a geographically defined U.S. population

Pages: n/a-n/a

Article date: February 2019

Authors: William V. Bobo, Brandon R. Grossardt, Maria I. Lapid, Jonathan G. Leung, Cynthia Stoppel, Paul Y. Takahashi, Robert W. Hoel, Zheng Chang, Christian Lachner, Mohit Chauhan, Lee Flowers, Scott M. Brue, Mark A. Frye, Jennifer St. Sauver, Walter A. Rocca, Bruce Sutor

Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain

Pages: n/a-n/a

Article date: December 2018

Authors: Yaping Hua, Waqas Azeem, Yunheng Shen, Shoude Zhang, Jan R. Olsen, Anne M. Øyan, Xisong Ke, Weidong Zhang, Karl‐Henning Kalland