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Pharmacology Research & Perspectives

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Levodopa‐carbidopa intestinal gel high concentration formulation is clinically bioequivalent to commercial formulation

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Article date: April 2019

Authors: Matthew Rosebraugh, Hari V. Kalluri, Wei Liu, Charles Locke, Dilraj Sidhu, Jian‐Hwa Han, Janet Benesh

Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

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Article date: April 2019

Authors: Si Xian Wong, Mun Yee Tham, Chee Leok Goh, Han Hui Cheong, Sui Yung Chan

Post‐MI treatment with G‐CSF and EPO‐liposome with SLX repairs infarcted myocardium through EPCs mobilization and activation of prosurvival signals in rabbits

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Article date: February 2019

Authors: Yoshihisa Yamada, Shingo Minatoguchi, Noriko Endo, Hiromitsu Kanamori, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Shinya Minatoguchi

A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques

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Article date: February 2019

Authors: David Sciberras, Christian Otoul, Françoise Lurquin, John Smeraglia, Aurélia Lappert, Steven De Bruyn, Jan Jaap van Lier

Diazepam is not a direct allosteric modulator of α1‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4

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Article date: February 2019

Authors: Lisa M. Williams, Xiaoji He, Tasneem M. Vaid, Alaa Abdul‐Ridha, Alice R. Whitehead, Paul R. Gooley, Ross A.D. Bathgate, Spencer J. Williams, Daniel J. Scott

Treatment with new organic nitrites in pulmonary hypertension of acute experimental pulmonary embolism

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Article date: February 2019

Authors: Kristofer F. Nilsson, Lars E. Gustafsson

Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

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Article date: February 2019

Authors: Lien Wang, Grace Lee, Amy Shih, Chester Kuei, Diane Nepomuceno, Michelle Wennerholm, Frances Fan, Jiejun Wu, Pascal Bonaventure, Timothy W. Lovenberg, Changlu Liu

Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

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Article date: February 2019

Authors: Dana C. Walters, Erwin E. W. Jansen, Garrett R. Ainslie, Gajja S. Salomons, Madalyn N. Brown, Michelle A. Schmidt, Jean‐Baptiste Roullet, K. M. Gibson

pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study

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Article date: February 2019

Authors: Angélique Stéphanou, Annabelle Ballesta

Frequency and predictors of the potential overprescribing of antidepressants in elderly residents of a geographically defined U.S. population

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Article date: February 2019

Authors: William V. Bobo, Brandon R. Grossardt, Maria I. Lapid, Jonathan G. Leung, Cynthia Stoppel, Paul Y. Takahashi, Robert W. Hoel, Zheng Chang, Christian Lachner, Mohit Chauhan, Lee Flowers, Scott M. Brue, Mark A. Frye, Jennifer St. Sauver, Walter A. Rocca, Bruce Sutor