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Pharmacology Research & Perspectives

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Article date: June 2019

Depressive disorders: Treatment failures and poor prognosis over the last 50 years

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Article date: June 2019

Authors: Thomas P. Blackburn

Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist

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Article date: June 2019

Authors: Tyler W. McCullock, Paul J. Kammermeier

Application of ultrasound‐guided cholecystocentesis to the evaluation of the metabolite profiling in bile of dogs and cynomolgus monkeys

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Article date: June 2019

Authors: Elizabeth A. Dierks, Chiuwa E. Luk, Hong Cai, Jamus MacGuire, Maxine Fox, James Smalley, R. Marc Fancher, Evan Janovitz, Kimberly Foster, Qin Sun

Preclinical characterization of AMPA receptor potentiator TAK‐137 as a therapeutic drug for schizophrenia

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Article date: June 2019

Authors: Maiko Tanaka, Akiyoshi Kunugi, Atsushi Suzuki, Noriko Suzuki, Motohisa Suzuki, Haruhide Kimura

l‐α‐Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK‐dependent pathway

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Article date: June 2019

Authors: Olivia J. Robertson‐Gray, Sarah K. Walsh, Erik Ryberg, Ann‐Cathrine Jönsson‐Rylander, Christopher Lipina, Cherry L. Wainwright

Identification of equol‐7‐glucuronide‐4′‐sulfate, monoglucuronides and monosulfates in human plasma of 2 equol producers after administration of kinako by LC‐ESI‐MS

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Article date: June 2019

Authors: Aki Obara, Mizuki Kinoshita, Kaori Hosoda, Akitomo Yokokawa, Hiromi Shibasaki, Kazuo Ishii

A structured literature review of interventions used in the management of nonalcoholic steatohepatitis (NASH)

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Article date: June 2019

Authors: Manca Povsic, Louisa Oliver, Neha Raju Jiandani, Richard Perry, Juliana Bottomley

Long‐term cardiovascular effects of vandetanib and pazopanib in normotensive rats

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Article date: June 2019

Authors: Samantha L. Cooper, Joanne J. Carter, Julie March, Jeanette Woolard

Leucine‐rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes

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Article date: June 2019

Authors: Daniela Mercatelli, Paolo Bolognesi, Martina Frassineti, Clarissa A. Pisanò, Francesco Longo, Derya R. Shimshek, Michele Morari