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Pharmacology Research & Perspectives

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The G protein–coupled estrogen receptor agonist, G‐1, attenuates BK channel activation in cerebral arterial smooth muscle cells

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Article date: July 2018

Authors: Kirk W. Evanson, Jacob A. Goldsmith, Payal Ghosh, Michael D. Delp

Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype

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Article date: July 2018

Authors: Pernilla Haage, Robert Kronstrand, Martin Josefsson, Simona Calistri, Ron H. N. Schaik, Henrik Green, Fredrik C. Kugelberg

The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects

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Article date: July 2018

Authors: Mark Johnson, Roxanne C. Jewell, Amanda Peppercorn, Elizabeth Gould, Jianfeng Xu, Yu Lou, Matthew Davies, Sandra Baldwin, Allan R. Tenorio, Matthew Burke, Jerry Jeffrey, Brian A. Johns

Drug conjugates—an emerging approach to treat breast cancer

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Article date: July 2018

Authors: Mahmud Hasan, Rehana K. Leak, Robert E. Stratford, Darius P. Zlotos, Paula A. Witt‐Enderby

Evaluation of morphine‐like effects of the mixed mu/delta agonist morphine‐6‐O‐sulfate in rats: Drug discrimination and physical dependence

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Article date: July 2018

Authors: Jai Shankar K. Yadlapalli, Shoban Babu Bommagani, Ryan D. Mahelona, Anqi Wan, Brenda M. Gannon, Narsimha R. Penthala, Maxim Dobretsov, Peter A. Crooks, William E. Fantegrossi

Potential role for histone deacetylation in chronic diazepam‐induced downregulation of α1‐GABAA receptor subunit expression

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Article date: July 2018

Authors: James Auta, Eleonora Gatta, John M. Davis, Subhash C. Pandey, Alessandro Guidotti

Serious hepatotoxicity following use of isoniazid preventive therapy in HIV patients in Eritrea

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Article date: July 2018

Authors: Mulugeta Russom, Merhawi Debesai, Mehari Zeregabr, Araia Berhane, Theodros Tekeste, Teklezghi Teklesenbet

Application of nSMOL coupled with LC‐MS bioanalysis for monitoring the Fc‐fusion biopharmaceuticals Etanercept and Abatacept in human serum

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Article date: July 2018

Authors: Noriko Iwamoto, Kotoko Yokoyama, Megumi Takanashi, Atsushi Yonezawa, Kazuo Matsubara, Takashi Shimada

Screening of anticancer drugs to detect drug‐induced interstitial pneumonia using the accumulated data in the electronic medical record

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Article date: July 2018

Authors: Yoshie Shimai, Toshihiro Takeda, Katsuki Okada, Shirou Manabe, Kei Teramoto, Naoki Mihara, Yasushi Matsumura

Vancomycin therapeutic drug monitoring and population pharmacokinetic models in special patient subpopulations

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Article date: July 2018

Authors: Joaquim F. Monteiro, Siomara R. Hahn, Jorge Gonçalves, Paula Fresco