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Pharmacology Research & Perspectives

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A novel soluble guanylate cyclase activator with reduced risk of hypotension by short‐acting vasodilation

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Article date: April 2019

Authors: Toshihiro Sawabe, Toshiki Chiba, Akihiro Kobayashi, Kosuke Nagasaka, Kazuyuki Aihara, Akiyuki Takaya

Levodopa‐carbidopa intestinal gel high concentration formulation is clinically bioequivalent to commercial formulation

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Article date: April 2019

Authors: Matthew Rosebraugh, Hari V. Kalluri, Wei Liu, Charles Locke, Dilraj Sidhu, Jian‐Hwa Han, Janet Benesh

Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease

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Article date: April 2019

Authors: Fernando L. Pagan, Michaeline L. Hebron, Barbara Wilmarth, Yasar Torres‐Yaghi, Abigail Lawler, Elizabeth E. Mundel, Nadia Yusuf, Nathan J. Starr, Joy Arellano, Helen H. Howard, Margo Peyton, Sara Matar, Xiaoguang Liu, Alan J. Fowler, Sorell L. Schwartz, Jaeil Ahn, Charbel Moussa

Issue Information

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Article date: April 2019

Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

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Article date: April 2019

Authors: Si Xian Wong, Mun Yee Tham, Chee Leok Goh, Han Hui Cheong, Sui Yung Chan

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes

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Article date: April 2019

Authors: Adam Joseph Bloom, Pan‐Fen Wang, Evan D. Kharasch

Phase I study of PF‐04895162, a Kv7 channel inhibitor, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

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Article date: February 2019

Authors: Michael D. Aleo, Jiri Aubrecht, Paul D. Bonin, Deborah A. Burt, Jennifer Colangelo, Lina Luo, Shelli Schomaker, Rachel Swiss, Simon Kirby, Greg C. Rigdon, Pinky Dua

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc

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Article date: February 2019

Authors: Motohiro Okada, Kouji Fukuyama, Yasuhiro Kawano, Takashi Shiroyama, Yuto Ueda

MDM2 inhibitor ameliorates cisplatin‐induced nephropathy via NFκΒ signal inhibition

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Article date: February 2019

Authors: Tomoyuki Fujikura, Hideo Yasuda, Takamasa Iwakura, Takayuki Tsuji, Hans‐J. Anders