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Pharmacology Research & Perspectives

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Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

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Article date: December 2018

Authors: Melanie Wannick, Siegfried Bezdek, Nathalie Guillen, Markus Thieme, Fibi Meshrkey, Sadegh Mousavi, Michaela Seeling, Falk Nimmerjahn, Attila Mócsai, Detlef Zillikens, Tanya Sezin, Christian D. Sadik

A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo

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Article date: December 2018

Authors: Sarah Donald, Mark Elliott, Bryony Gray, Fraser Hornby, Agnieszka Lewandowska, Sandra Marlin, Christine Favre‐Guilmard, Cindy Périer, Sylvie Cornet, Mikhail Kalinichev, Johannes Krupp, Elena Fonfria

Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain

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Article date: December 2018

Authors: Yaping Hua, Waqas Azeem, Yunheng Shen, Shoude Zhang, Jan R. Olsen, Anne M. Øyan, Xisong Ke, Weidong Zhang, Karl‐Henning Kalland

Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies

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Article date: December 2018

Authors: Chiara Ruzza, Federica Ferrari, Remo Guerrini, Erika Marzola, Delia Preti, Rainer K. Reinscheid, Girolamo Calo

Pharmacokinetics and safety of Enasidenib following single oral doses in Japanese and Caucasian subjects

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Article date: December 2018

Authors: Yan Li, Liangang Liu, Diana Gomez, Jian Chen, Zeen Tong, Maria Palmisano, Simon Zhou

Natural language processing‐based assessment of consistency in summaries of product characteristics of generic antimicrobials

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Article date: December 2018

Authors: Rumiko Shimazawa, Yoshinobu Kano, Masayuki Ikeda

Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model

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Article date: December 2018

Authors: Vishnu Chintalgattu, Joanne Greenberg, Shivani Singh, Venice Chiueh, Amy Gilbert, Jason W. O'Neill, Stephen Smith, Simon Jackson, Aarif Y. Khakoo, TaeWeon Lee

Nonclinical safety assessment of a human interleukin‐22FC IG fusion protein demonstrates in vitro to in vivo and cross‐species translatability

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Article date: December 2018

Authors: Donna W. Lee, Shelly Zhong, Rama Pai, Julie Rae, Siddharth Sukumaran, Eric G. Stefanich, Jeff Lutman, Estelle Doudement, Xiaoting Wang, Brandon Harder, Annemarie Lekkerkerker, Ann Herman, Wenjun Ouyang, Dimitry M. Danilenko

Cellular density‐dependent increases in HIF‐1α compete with c‐Myc to down‐regulate human EP4 receptor promoter activity through Sp‐1‐binding region

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Article date: December 2018

Authors: Naofumi Seira, Kazuyuki Yamagata, Keijo Fukushima, Yumi Araki, Naoki Kurata, Naoki Yanagisawa, Masato Mashimo, Hiroyuki Nakamura, John W. Regan, Toshihiko Murayama, Hiromichi Fujino