Article date: December 1971
By: B. G. BENFEY in Volume 43, Issue 4, pages 757-763
Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.
Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.
This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines.
Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.
Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.
This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines.
DOI: 10.1111/j.1476-5381.1971.tb07211.x
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