PRESENCE OF KALLIKREIN IN THE γ‐GLOBULIN PERMEABILITY FACTOR OF GUINEA‐PIG SERUM

Article date: December 1963

By: G. E. DAVIES, J. S. LOWE in Volume 21, Issue 3, pages 491-499

γ‐Globulin fractions isolated from guinea‐pig serum by chromatography on diethyl‐aminoethyl cellulose exhibited all the properties of kallikrein. From a range of amino acid esters tested, only esters of arginine and lysine were hydrolysed; the esterase and capillary permeability‐increasing activities of different samples were correlated. Both esterase and permeability‐increasing activities could be increased by the addition of certain albumin‐rich fractions or of glass beads previously treated with guinea‐pig serum.

DOI: 10.1111/j.1476-5381.1963.tb02017.x

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