THE EFFECT OF PIPERAZINE ON SUCCINATE PRODUCTION BY ASCARIS LUMBRICOIDES

Article date: December 1959

By: E. BUEDING, H. J. SAZ, G. W. FARROW in Volume 14, Issue 4, pages 497-500

Piperazine reduced the production of succinate by Ascaris lumbricoides. This effect was reversible. There was a close parallelism between the concentrations of piperazine which paralysed the worm and those which inhibited the formation of succinate. Piperazine did not affect the incorporation of [2‐14C]lactate into succinate by strips of Ascaris muscle. It was concluded that production of succinate supplies energy for the contraction of Ascaris muscle.

DOI: 10.1111/j.1476-5381.1959.tb00955.x

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