Article date: December 1959
By: A. H. KITCHIN, H. KONZETT, MARY PICKFORD in Volume 14, Issue 4, pages 567-570
Valyl3‐oxytocin has similar circulatory effects in man to those of Syntocinon (synthetic oxytocin). On intravenous administration, it caused a rise in limb blood flow and in pulse rate and a fall in blood pressure. It had a direct vasodilator effect on limb blood vessels. Valyl3‐oxytocin was 1.5 to 2 times more potent than Syntocinon in terms of its circulatory effect in man. The circulatory effects of valyl3‐oxytocin were less readily antagonized by vasopressin than are those of Syntocinon.
DOI: 10.1111/j.1476-5381.1959.tb00965.x
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