Article date: December 1959
By: MURIEL E. FARQUHARSON, R. G. JOHNSTON in Volume 14, Issue 4, pages 559-566
Methods of testing new drugs for anti‐Parkinson activity are briefly reviewed. The production in animals of Parkinson‐like effects by Tremorine (1,4‐dipyrrolidin‐1′‐ylbut‐2‐yne), and the inhibition of these effects in mice by a number of tropine derivatives, are described. No correlation was found between the activity against tremor and the anticholinergic, antihistaminic or local anaesthetic properties of the compounds.
DOI: 10.1111/j.1476-5381.1959.tb00964.x
View this article