Article date: April 1985
By: F Theeuwes, DR Swanson, G Guittard, A Ayer, S Khanna, in Volume 19, Issue S2, pages 69S-76S
The essential features and mode of action of oral osmotic drug delivery systems (Oros) for metoprolol fumarate and oxprenolol succinate are described. Critical aspects in the development of systems for once‐ daily administration of both drugs are discussed, and methods for evaluating in vitro release characteristics are presented. In vitro testing confirmed that drug delivery corresponded closely to the theoretical release behaviour predicted from the physicochemical and membrane permeability characteristics for both oxprenolol and metoprolol systems. In vitro release rates were also shown to be unaffected by pH, in vitro test procedures, dissolution media and long‐ term storage at different temperatures.
DOI: 10.1111/j.1365-2125.1985.tb02745.x
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