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12th International Symposium on Resistance Arteries

The latest developments in research into the function of the resistance vasculature and closely related topics.

03–06 Sep 2017

Abstracts deadline: 30 Jun 2017

Registration deadline: 18 Aug 2017

Manchester, UK - View map

  • Overview
  • Event programme
Registration: £300
Early bird registration (before 31 May 2017): £250

More information and registration

The 12th International Symposium on Resistance Arteries is a focused multidisciplinary conference where international experts in all aspects of vascular function present and discuss the latest developments in research into the function of the resistance vasculature and closely related topics. The meeting has sessions focusing from the molecular level and cellular communication all the way through to the latest clinical developments and perspectives in humans.

The final programme highlights some recent paradigm shifts in our understanding of how the resistance vascular is controlled by peri- and non-vascular cell types. For example, the role of the capillary network and associated cells such as pericytes in the control and modulation of blood flow and arterial tone in the brain; findings that look set to have profound implications in the treatment of associated neurological disorders and correlates  in the systemic circulation. The programme also highlights other novel targets amenable to pharmacotherapy and exciting developments in the fields of vascular cell signalling, interaction with other cells/tissues and clinical perspectives of the role of resistance vasculature dysfunction, inflammation and even atherosclerosis.

Highlights include Plenary sessions from Ulrich Pohl and Mark Nelson. National and international invited speakers including J. Jaggar (USA), T. Haas (Canada), T. Jepps (Denmark), G. Drummond (Australia), A. Hobbs (UK), E Eringa (Amsterdam), H. Li (Germany), M. Bennett (UK).
Oral presentations and Poster presentations will feature young investigators. Young Investigator and poster awards will be available.
The conference will consist of an opening ceremony on the 3rd September followed by three full days of talks, poster presentations and opportunity to interact. Our preliminary programme is such that days will be delivered in the following format (subject to change)-

ISRA2017- Sunday evening Plenary: 5-6 pm. Mark Nelson: “Vascular Control
Time Monday 4th
Tuesday 5th Wednesday 6th
8.00-10.00 SESSION 1: Channels & Exchangers SESSION 1: Regulation SESSION 1: Structural
  J. Jaggar (USA) – Vascular Control by Ion Channel Trafficking
A. Albert (UK) -Store-operated channels in contractile vascular smooth muscle cells: Role of TRPC1 and Orai1?
E. Boedtker (Denmark)-Transport and sensing of HCO3– modify resistance artery function: consequences for blood pressure and metabolic regulation of tone
E. Honore (France) – Title TBC
T. Haas (Canada)- Modulation of angiogenesis by anti-angiogenic factors
K. Sward (Sweden)- Notch provides a constitutive drive for expression of soluble guanylyl cyclase in the vascular wall that is inhibited by hypertension
M Cipolla (USA) – Regulation of vascular resistance in the brain: Physiology and pathophysiology
 Speaker 4 – TBC
M. Navedo (USA) -Purinergic signaling in diabetic resistance arteries
M. Mederos Y Schnitzler (Germany)- The role of GPCRs for mechanosensation in arteries
T. Jepps (Denmark) – Regulation of arterial tone by ancillary KCNE subunits
G. Meininger (USA) – Relationships between cell adhesion and vascular smooth muscle contractile function
10.00-10.20 Coffee Coffee Coffee
10.20-12.30 SESSION 2: Interaction other cells SESSION 2: Interaction other cells SESSION 2: Interaction other cells
  T. Longden  (USA) – Capillary-to-arteriole communication regulates blood flow into the brain
C. Tran (Canada)- Alteration to cerebral hemodynamics modifies astrocytes Ca2+activity in awake, behaving mice
G. Drummond (Australia)-B cell-mediated immunity and hypertension.
Catherine Hall (UK) – Regulation of cerebral blood flow by pericytes
L. Santana (USA)- Title TBC
A. Hobbs (UK) –Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide.
Speaker 3 – TBC
Speaker 4 – TBC
M.  Fernández-Alfonso (Spain)-Role of perivascular adipose tissue on vascular function in health and disease
E Eringa (Amsterdam)-Adipo-endothelial cross-talk as a driver of resistance artery dysfunction in the metabolic syndrome
R Ganss (Australia) – Remodelling Vasculature: New Approaches to Therapy
S Davidge (Canada) – Pregnancy complications and programming of vascular dysfunction in adult offspring
13:30-16:00 Free time Free time Plenary Speaker

U. Pohl-Reflections
Early Career Researchers
Speaker 1 – C Wilson – Mitochondria / endothelium (Strathclyde UK)
Speaker 2 – S Saxton (UK) – Title TBC
Speaker 3 – From submissions
Speaker 4 – From submissions
16:00-18:00 Moderated posters and vendors Moderated posters and vendors  
19:30-20:15 Special: C.  Aalkjaer Title TBC Special: Speaker TBC
20:15-21:30 SESSION 3: Clinical scenarios SESSION 3: Clinical scenarios  
  H. Li (Germany) – Role of perivascular adipose tissue in obesity-induced vascular dysfunction
D.  Stepp  (USA) -Novel mechanisms of altered vasomotor tone in obesity
A. Briones (Spain) – Novel mechanisms of vascular damage in hypertension
M. Bennett (UK) – Life, death and old age : role of vascular smooth muscle cells in atherosclerosis
X Yao (Hong kong)-Role of TRPC1 in vascular tone regulation

Speaker 3– TBC