The IUPHAR/BPS Guide to PHARMACOLOGY is an online expert-driven database of drug targets and their ligands. The site has been created in collaboration between The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR).
The Guide to PHARMACOLOGY provides concise, peer-reviewed overviews of the key properties of over 2000 established and potential drug targets, with more detailed information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB; the original database of the IUPHAR Nomenclature Committee) and the published BPS 'Guide to Receptors and Channels' (GRAC) compendium, which has now been superceded by the Concise Guide to PHARMACOLOGY. The data in Guide to PHARMACOLOGY are curated from the primary literature by a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the ∼7000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. The Guide to PHARMACOLOGY is useful for researchers and students in pharmacology and drug discovery, and will provide the general public with accurate information on the basic science underlying drug action.
The Concise Guide to PHARMACOLOGY is a biennial snapshot of the succinct overviews and key properties of each target family in the database, intended to be a quick desktop reference guide. It replaces GRAC, and is published in PDF format at two yearly intervals as a supplement to the British Journal of Pharmacology.
The Guide to PHARMACOLOGY is developed by the database team within the Centre for Integrative Physiology at the University of Edinburgh:
Jamie A. Davies - Database Principal Investigator
Joanna L. Sharman - Database Developer
Adam J. Pawson - Senior Database Curator
Helen E. Benson - Database Curator
Elena Faccenda - Database Curator
Christopher Southan - Chemical Curator
Veronika Divincova - Project Administrator