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Recruiting for Deputy Editor, Pharmacology Research and Perspectives

Pharmacology Research and Perspectives (PR&P) is an open access journal jointly owned by: American Society for Pharmacology and Experimental Therapeutics (ASPET), British Pharmacological Society (BPS) and John Wiley & Sons (publisher).

Pharmacology Research and Perspectives (PR&P) is seeking to appoint a new Deputy Editor to take over the role from 1 January 2016. The new Deputy Editor will work with the current Deputy Editor Dr Darrell Abernethy (Editor-in-Chief from 1 January 2016) to continue to build on the success of the journal. Dr Abernethy replaces Dr Mike Curtis who completes his term as inaugural Editor-in-Chief at the end of the year.

Full job description

The deadline for applications is 17 July 2015. Please direct any questions to Ruth Meyer.

MRC MRes programme in in vivo sciences, MRes in Vascular and Cellular Inflammation William Harvey Research Institute, London, UK

The William Harvey Research Institute is currently the UK’s largest academic pharmacological research institute and has a long history of training talented scientists for careers in translational research (www.whri.qmul.ac.uk). We are now seeking outstanding life sciences graduates for our MRC funded 1 year MRes programme in in vivo sciences to commence in October 2013. During the year students will obtain a comprehensive training in in vivo techniques, key laboratory skills, research governance, the application of state-of-the-art imaging techniques and generic transferable skills followed by an opportunity to conduct an in-vivo based research project. The highest ranking students may be offered the opportunity to build upon their MRes studies and conduct a fully-funded 3 year PhD within the WHRI with their chosen supervisor. For further information on the course visit their website

All students will be based in the attractive Charterhouse Square campus in the City of London with access to exceptional scientific and recreational facilities.

This training will be an invaluable foundation for individuals wishing to pursue a career in industry or academic research, particularly in the areas of inflammation science, cardiovascular research or cell signaling. Successful applicants will receive an award covering tuition fees and a bursary at the current MRC rate for 1 year.

This studentship is funded by the Medical Research Council and comes with a tax-free stipend of £15, 863 per annum. This studentship is open to UK Nationals, EEA/Swiss migrant workers and non-UK nationals with indefinite leave to remain in the UK who all have three years ordinary residence in the UK prior to the start of the studentship.

For further information, please contact Dr Nina Ravic Email: n.ravic@qmul.ac.uk. To apply online please go to their website.

Please also email a current copy of your CV to the course supervisor. Your referees should also email references directly to the course supervisors: Prof. Amrita Ahluwalia (a.ahluwalia@qmul.ac.uk), Prof. Fulvio D’Acquisto (f.dacquisto@qmul.ac.uk) or Prof. Paul Chapple (j.p.chapple@qmul.ac.uk).

Interviews scheduled from the week beginning 9th June 2015. The closing date for applications is 29 May 2015.

Clinical Pharmacologists, GlaxoSmithKline, Stevenage and Uxbridge (UK) and Upper Merion (USA

The department of Clinical Pharmacology Modelling and Simulation at GlaxoSmithKline is recruiting several quantitative Clinical Pharmacologists, at levels from Scientist to Senior Director. Successful candidates will have the opportunity to work on both small molecules and biologics in therapy areas including: immunoinflammation, metabolic pathways, respiration, oncology, infection, neurosciences, dermatology, cardiovascular diseases and others. Positions are based in Stevenage and Uxbridge in the UK and in Upper Merion in the USA.

GlaxoSmithKline provides a supportive environment for scientists who are aspired to learn, to contribute and to make impact on business decisions through innovation. We have several vacancies. The position level for a successful candidate will be based on the person’s skills and experience

Responsibilities may include:

• Contribute, as a member of a multi-discipline team, to the design of an efficient clinical development program and a robust registration package
• Play a central role in predicting human dose range, characterising dose-response relationship and justifying dose recommendations for special populations
• Develop mathematical and statistical models to understand a disease, its progression, and pharmacodynamics and pharmacokinetics; conduct meta-analyses as appropriate to maximise data use; conduct simulations to assess trial design performance
• Design and interpret clinical pharmacology studies, including those to evaluate potential effects of intrinsic and extrinsic factors on pharmacokinetics and pharmacodynamics
• Write sections of drug development and registration documents such as clinical trial protocols and reports, clinical investigator brochures and regulatory submission packages
• Present and defend quantitative clinical pharmacology plans and results through interaction and negotiation with internal governance committees and external regulators
• Innovate through working effectively with colleagues in the department and others such as statisticians, biologists, physicians and drug metabolism scientists
• Learn and apply emerging modelling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; collaborate with external field-leading teams for methodology application
• Promote model-informed drug development approach by publishing in peer-reviewed journals and presenting at scientific conferences

Essential and preferred requirements are:

• Advanced training with a degree such as PhD, PharmD and MD to enable a successful career in quantitative clinical pharmacology in pharmaceutical research and development
• Knowledge of or ability to quickly learn the mechanism, endpoints, progression and treatments of relevant diseases
• Understanding of pharmacokinetic and pharmacodynamic principles and commonly applied models; working knowledge of common tools for quantitative clinical pharmacology such as NONMEM, R, WINNONLIN, Simcyp, SAS and MATLAB
• Experience in designing, analysing and reporting clinical studies, with a simulation- or modelling-based approach where appropriate
• Familiarity with regulatory submission documents such as CTAs, INDs, NDAs, MAAs and BLAs
• Ability to communicate clearly and succinctly with the audience in mind, both orally and in writing
• Ability to build effective collaboration while taking personal accountability for delivery of quantitative clinical pharmacology results
• Sound judgement, analytical mindset and problem-solving skills
• Ability to effectively multi-task and deliver results on time

To apply visit their website.

The closing date for applications is 22 May 2015.

Postdoctoral Research Assistant

A dedicated and self-motivated scientist is required to work on a project investigating the mechanisms that control arterial tone in the microcirculation and the dysfunction caused during diabetic vascular disease.

The research will use in vitro approaches, including live cell imaging, and training will be provide in all the techniques. Applicants should have a PhD in an area of Biomedical Science and an interest in cardiovascular physiology/pharmacology. S/he should be able to work independently but also as part of a team, and have strong oral and written communication skills, with a publication record appropriate to their career stage.

The project is part of a collaboration between Professors Chris Garland and Kim Dora in Oxford and Professor Chris Triggle and Dr Hong Ding at the Weill-Cornell Medical School in Qatar. The post will be based in the Department of Pharmacology in Oxford and is available immediately for up to twelve months in the first instance. It is funded by the Qatar National Research Fund.

Details of the Oxford group's research and recent publications can be found at: www.pharm.ox.ac.uk/research.

To discuss this opportunity further please send an email to christopher.garland@pharm.ox.ac.uk or kim.dora@pharm.ox.ac.uk.

Research Scientist (SPR), UCB-New Medicines, Slough, UKB

Department: Discovery Biology - PPG
Job Hours: Full-Time
Requirements: BSc (or equivalent), plus several years experience in relevant setting

UCB aspires to be the patient-centric global biopharmaceutical leader transforming the lives of people living with severe diseases. We focus on central nervous system and immunology disorders and our goal is to help tackle the serious unmet medical needs affecting patients around the globe. Our philosophy is to take a holistic approach and develop both innovative medicines and ground-breaking treatment solutions that go beyond the drug and are tailored to our patients’ individual needs.

Our discovery research to clinical proof-of-concept arm of our organization, UCB New Medicines, has the responsibility for developing our rich pipeline of differentiated molecules and is committed to being a leader in cutting-edge scientific research that is driven by the needs of patients’. Our world class research centres in Slough and Braine are home to a wealth of skills and experience and our proprietary technology platforms enable the discovery and development of novel therapeutic entities. We have well established and highly effective networks with the leading academic establishments and industrial partners which enable us to access novel technologies, targets and collaborative research.

The Primary Pharmacology Group in Slough is looking to recruit a research scientist with an interest in biochemical assay technologies and in particular, SPR (surface plasmon resonance) experience to play a key role in expanding our capabilities for characterization of antibody and small molecule entities. As an SPR scientist within PPG at UCB you will be responsible for the design, development and prosecution of assays to both identify and characterise the relevant binding activity of both small molecule and antibody candidates, which is vitally important for ensuring translation through the drug discovery process and ultimately the effective, identification of safer drugs to treat human disease, and benefit to patients.

We are seeking highly motivated individuals who have a keen interest in the biochemical study of molecular interactions and ideally experience in SPR, who are able to deliver high quality results, as well as having effective problem solving skills and strong interpersonal skills.

Responsibilities

• Design, development and prosecution of a variety of SPR and other biochemical /biophysical assays
• Proactive communication and partnership with other groups within and outside own functional area to gain credibility and impact in science, technology and project progression
• Keep abreast of and implement technology developments within the area of biophysical techniques for understanding the molecular interactions and kinetics of potential therapeutics

To apply please go to our website via the 'Apply Now' button or via www.ucb.com and follow the link to our Job Seekers page. Only candidates able to work in the EU will be considered for this role.

The closing date for applications is Sunday 31 May 2015.

Senior Scientist/Principal Scientist (Cell Biology), UCB-New Medicines, Slough, UK

Department: Discovery Biology - PPG
Job Hours: Full-Time
Requirements: PhD (or equivalent)

UCB aspires to be the patient-centric global biopharmaceutical leader transforming the lives of people living with severe diseases. We focus on central nervous system and immunology disorders and our goal is to help tackle the serious unmet medical needs affecting patients around the globe. Our philosophy is to take a holistic approach and develop both innovative medicines and ground-breaking treatment solutions that go beyond the drug and are tailored to our patients’ individual needs.

Our discovery research to clinical proof-of-concept arm of our organization, UCB New Medicines, has the responsibility for developing our rich pipeline of differentiated molecules and is committed to being a leader in cutting-edge scientific research that is driven by the needs of patients’. Our world class research centres in Slough and Braine are home to a wealth of skills and experience and our proprietary technology platforms enable the discovery and development of novel therapeutic entities. We have well established and highly effective networks with the leading academic establishments and industrial partners which enable us to access novel technologies, targets and collaborative research..

The Primary Pharmacology Group in Slough is looking to recruit a number of senior research / principal scientists with extensive cell-based systems experience to play a pivotal role in expanding our capabilities for characterization of antibody and small molecule entities in cellular systems. As a cell biologist within PPG at UCB you will be responsible for the design, development and prosecution of assays to both identify and characterise the relevant biological activity of both small molecule and antibody candidates, which is vitally important for ensuring translation through the drug discovery process and ultimately the effective, identification of safer drugs to treat human disease, and benefit to patients.

We are seeking a number of individuals who have a high degree of experience in cell biology, with techniques such as human primary cell systems or co-culture systems along with technologies such as flow cytometry or high-content imaging, who have a proven track record for delivering high quality results, an extensive publication history and strong interpersonal skills.

Responsibilities

• Independent design, development and prosecution of a variety of in vitro cell-based assays
• Proactive communication and partnership with other groups within and outside own functional area to influence science, technology and project progression
• Build cell-biology expertise within PPG through influencing, mentoring and networking, in particular establishing effective external collaborations
• Represent UCB at major international conferences and publish relevant work

To apply please go to our website via the 'Apply Now' button or via www.ucb.com and follow the link to our Job Seekers page. Only candidates able to work in the EU will be considered for this role.

The closing date for applications is Sunday 31 May 2015.

PhD position in Cardiovascular Toxicity, University of Cambridge – Department of Pharmacology and AstraZeneca


Applications are invited for a fully-funded PhD position for Home (UK)/EU students in the Department of Pharmacology at the University of Cambridge. The studentship is fully funded by AstraZeneca and will be based within the Department of Pharmacology, which offers comprehensive facilities for research in a modern building located in the centre of Cambridge.

Project Information
A new drug must be effective but also safe. Cardiovascular toxicities associated with drugs, including vascular damage, thrombosis and heart failure, are a major reason for drugs to be withdrawn from development or after approval. A further important challenge is to predict the risk of cardiovascular toxicity in patients with an already higher risk of cardiovascular disease, such as diabetic patients. Therefore, there is a pressing need for new models that accurately predict human vascular injury in healthy and at-risk patients.

In this project we will use human blood vessels in a new ex vivo model of drug-induced vascular damage and thrombo-inflammation. We will use high-resolution imaging and biomarker analysis to investigate how drugs influence vessel reactivity, inflammation and thrombosis in healthy and diseased blood vessels. In this way we will provide new mechanistic insights into how drugs cause blood vessel damage.

Applicants must have, or should expect to gain, a minimum of a 2.1, or equivalent, in pharmacology (or a related subject such as biochemistry, physiology or cellular and molecular biology). UK students who meet the UK residency requirements will be eligible for a full studentship (stipend currently £17,000 p.a.). EU students will also be eligible for a full studentship.

Further information can be obtained from Dr Matthew Harper (http://www.phar.cam.ac.uk/research/harper/Summary).

Applications should be made on-line via the Cambridge Graduate Admissions Office before the deadline.

The closing date for applications is 15 June 2015 .

Head of Pharmacological Research BIAL, University of Porto, Portugal

Founded in 1924 Bial is Portugal’s largest pharmaceutical company with revenues > 200M EUR. In the Portuguese market itself it ranks third in terms of market share.

The Head of Pharmacological Research will be responsible for planning, organising and coordinating the activities of the Pharmacological Research laboratory in order to manage, align, maximise and achieve the goals set. A strong pre-clinical and clinical pharmacological skill set is vitally important in this new hire. Equally important will be the ability to operate in a thriving family business across functions. Candidates must have a clear understanding of the transition from the pre-clinical to clinical setting, and an understanding of the triangulation between pre-clinical, clinical and chemical drug development from a pharmaceutical background. Ideally, they should possess relevant therapy area knowledge in Cardiovascular and/or CNS.

This position reports into Professor Soares-da-Silva, Director of Research & Development and Professor of Therapeutics and Clinical Pharmacology in the Faculty of Medicine at Porto University. Professor Soares-da-Silva in turn reports directly into the CEO of the Company, and so this represents a unique opportunity to be closely aligned with the most senior management of the Company. With 5 direct reports and a team of 18, this represents an exciting opportunity to join a Company with significant plans for growth and in an R&D team that is highly strategic. A significant degree of international travel is expected. The closing date for applications is 26 June 2015.
Full job description

For a detailed conversation about this opportunity, please contact:

Natalie Hall
Research Associate, ODGERS BERNDTSON
natalie.hall@odgersberndtson.com (+44207 518 2616)

Educator Track (Lecturer or Senior Lecturer), National University of Singapore, Singapore

Position:

The National University of Singapore (NUS) Yong Loo Lin School of Medicine invites applications for one Educator Track (Lecturer or Senior Lecturer) faculty position in the Department of Pharmacology.

Qualifications and Requirements:

Candidates must hold a PhD or equivalent Degree, possess excellent communication skills, and have good record of research experience and publications. Candidates with established and good teaching record, and wide-ranging teaching experience will be preferred.

Job Scope:

Successful candidate is expected to deliver significant teaching load to 5 major groups of undergraduate students:

i. Medical
ii. Dental
iii. Pharmacy
iv. Nursing
v. Life Sciences

Candidate is expected to contribute to the teaching initiatives of the department, to deliver existing courses and to manage different class sizes (lectures and smaller classes). Candidate is expected to excel in teaching and educational leadership including curriculum design, new materials developments including e-learning, student consultations, student supervisions and student assessments.

Remuneration and level of appointment will commensurate with qualifications and experience. The position is full-time educator track, usually of a three-year term contract in the first instance.

Interested candidates should submit their applications with the following supporting documentation:

i. Cover letter
ii. A detailed CV
iii. Teaching statements and philosophy
iv. Evaluation on teaching from faculty members or students of current institution
v. Course syllabus and specific teaching experience
vi. Minimum of 3 reference letters

Please submit your application to A/Prof Fred Wong Wai‐Shiu, Head, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Level 5, Clinical Research Centre, Block MD11, 10 Medical Drive, Singapore 117597, Email: phchead@nus.edu.sg.

Shortlisted candidates may be invited for a campus visit. The closing date for applications is 30 June 2015.

Assistant Professor, National University of Singapore, Singapore

Position

The National University of Singapore (NUS) Yong Loo Lin School of Medicine invites applications for a Tenure‐track Full‐time Assistant Professor position in the Department of Pharmacology. The Department has major conglomerations of strength in cancer pharmacology and neuropharmacology research (more information on the department is available at http://medicine.nus.edu.sg/medphc/ ). We are looking for candidate with strong research interests in immunopharmacology, cardiovascular pharmacology, or pharmacokinetics/pharmacogenomics to build on our existing strength.

Main duties and responsibilities

The Assistant Professor will be expected to compete for independent extramural research funding; is required to participate in undergraduate and/or graduate level teaching of medical, dental, nursing, pharmacy and life science students; and will be expected to contribute to service to the Department and University as assigned by the Head of Department. The Assistant Professor will be expected to establish excellence in research and education meriting promotion to Associate Professor with tenure within 6 years.

Qualifications

The applicant should:

(a) have a Ph.D. in pharmacology or related disciplines
(b) have experience in teaching demonstrating potential for development as an outstanding educator
(c) have a strong track record of research demonstrating potential for development as an outstanding researcher; preferably with at least 4‐6 years postdoctoral training, and
(d) have research expertise relevant to pharmacology, preferably with focus on immunopharmacology, cardiovascular pharmacology, or pharmacokinetics/pharmacogenomics.

Please submit your application to A/Prof Fred Wong Wai‐Shiu, Head, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Level 5, Clinical Research Centre, Block MD11, 10 Medical Drive, Singapore 117597, Email: phchead@nus.edu.sg.

Only shortlisted candidates will be notified. The closing date for applications is 30 June 2015 .

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