Translational and Development Pharmacologist, Astellas
      Lecturer In Pharmacology, Bradford School of Pharmacy, University of Bradford, UK
      Senior Research Scientist, Pneumolabs, Harrow, UK
      Research Scientist, Inflammation Research, Pneumolabs, Harrow, UK
      PhD Studentship, School of Pharmacy, University of Reading, Reading, UK

About Astellas:
Astellas is an international pharmaceutical company employing over 16,000 people worldwide and with combined global sales of over 7 billion euro. The company’s European headquarters are based in London, with affiliates throughout Europe working in production, sales & marketing, and research & development. With almost 4,000 employees, Europe is an important and growing Astellas region, having key strengths in the therapy areas of Urology, Dermatology, Transplantation, Anti Infectives, Pain Management and Oncology. The Mirai House, located in Leiden Bio Science Park (the Netherlands) is home to the European R&D organization focusing on the development of medicines in the areas of Pain, Urology and Diabetes/Metabolic diseases. An R&D investment budget of 15-20% is evidence of the company’s commitment to improving the health of people worldwide through the provision of innovative and reliable products. The Mirai House is also hosting Astellas Pharma Netherlands (the Dutch affiliate) and Astellas Pharma International. Astellas Pharma International is present in the Near & Middle East, Africa and some other selected countries.

The job:
For our Drug Discovery Research organization we are looking for an experienced Translational Scientist to provide scientific and strategic Translational Science leadership for Astellas targets and products. In this role you will give lead in defining Translational Science opportunities e.g. omics, biomarkers and bio-imaging to enable informed decision making on Astellas development projects. As pharmacology expert you will contribute to patient oriented assessments and integration of non-clinical data towards human efficacy and safety prediction. You will become member of the Translational & Development group and work globally in multidisciplinary project teams.

Your personal qualifications:

• PhD in Bio-sciences, Pharmacy, Medicine or equivalent
• 5+ Years experience in (non)-clinical research and translational medicine in pharmaceutical company or research driven organization
• Hands on experience in preparing Translational Science strategies
• Good understanding of drug development processes
• Expert in non-clinical pharmacology and disease biology preferably in Chronic Kidney Disease/Nephrology
• Global team player and critical analytical skills
• excellent communication skills.

We offer:

• A challenging and diversified job
• Good career opportunities
• Inspiring work climate
• Brand new location (Mirai House) in Leiden
• Attractive remuneration.

Candidates are requested to contact: Recruitment.nl@astellas.com

Vacancy Ref: ALS1234
Grade 9 Salary: £38,522 - £44,607 per annum
Term: One year fixed term post

The Bradford School of Pharmacy launched a pioneering MPharm curriculum in 2012, based on principles of integration of science and practice and team-based learning. To allow us to meet the demands of the transition between the existing curriculum and curriculum 2012, we seek a lecturer in Pharmacology for one year. You will work under the direction of the MPharm programme leader, Dr Di Wood, and deliver lectures and practicals across a range of topics within pharmacology, human physiology and therapeutics to pharmacy, biomedical sciences and clinical sciences students. You will also be expected to lead three well-established modules.

We welcome applicants with the desire and aptitude to contribute to our teaching programme. The successful applicant will have teaching experience, ideally from teaching pharmacy students. You will be willing and enthusiastic in developing your teaching skills, and have the opportunity to help us develop our innovative, integrated pharmacy curriculum.

For further information about this post and on-line application go to: www.bradford.ac.uk/jobs.Vacancy Ref: ALS1234. Starting salary dependent on experience and qualifications.

Interview Date: 15 July 2013. The closing date for applications is 28 June 2013.

Pneumolabs is a small preclinical research services company specialising in a wide range of tests/models of Inflammation with a main focus on Respiratory Disease. We are based in North London where we have our own self contained laboratories. You will be part of a team which interacts with Pharma so a good level of communication and self motivation are necessary. You will supervise Research Scientists and be responsible for establishing, planning, running and analysing a range of tests/models of Inflammation.

You must hold a PhD or BSc/ MSc in a relevant biological science with at least 5 years experience in Inflammation research predominantly in vivo.

The Role:

A senior member of the preclinical research service team, you will be responsible for establishing and running a wide range of tests or models of Inflammation with focus on Respiratory Disease. You will supervise Research Scientists and interact with clients to assist in the planning and interpretation of their studies.

Key responsibilities:

• Establish and run a range of tests/models.
• Supervise Research Scientists on a daily basis.
• Maintain an accurate record of all studies undertaken and data generated.
• Actively participate in meetings with potential and ongoing clients to help in planning and interpretation of their studies.
• Chair regular laboratory and strategic meetings

Required Qualifications - Education/Work Experience:

• PhD, BSc or MSc in relevant biological science with at least 5 years experience ideally in Inflammation research but applicants with experience of in vivo testing in other disease areas will be considered.

Personal Qualities:

• Excellent communication, organisational and supervisory skills
• Strong IT skills
• Work without supervision
• A team player

To enquire further or apply, please send your CV and a covering e-mail to phillip.gardiner@pneumolabs.co.uk

The closing date for applications is 1 September 2013.

Pneumolabs is a small preclinical research services company specialising in a wide range of tests/models of Respiratory Disease. We are based in North London where we have our own self-contained laboratories. We currently have vacancies for graduates in Pharmacology or an equivalent qualification. You will be part of a team, which interacts with Pharma at all levels so a good level of communication and self-motivation are necessary. You will be responsible for organising, running and analysing a range of tests/models of Inflammation with the main focus on Respiratory diseaSE.

You must hold a BSc or MSc in a relevant biological science and be proficient in a range of IT skills.

The Role

As a member of the preclinical research service team, you will help to establish and run a wide range of tests or models of Inflammation. You will analyse and assist in the interpretation and reporting of client studies in conjunction with Senior Scientists in the team.

Key responsibilities

• Set up and run a range of tests/models under the supervision of Senior Research Scientists
• Analyse and assist in the interpretation and reporting of client studies
• Maintain an accurate record of all studies undertaken and data generated
• Assist in running an active suite of laboratories, monitoring and ordering consumables as required
• Actively participate in regular laboratory and strategic meetings

Required Qualifications - Education/Work Experience

• BSc in relevant biological science
• Previous experience of working in a laboratory environment desirable but not critical

Key responsibilities

• Excellent communication and organisational skills
• Strong IT skills
• Work with or without supervision
• A team player

To enquire further or apply, please send your CV and a covering e-mail to phillip.gardiner@pneumolabs.co.uk

The closing date for applications is 1 August 2013.

Title: Development of ion channel ‘intrabodies’ as novel drug discovery tools
Start Date: October 2013
Duration: 3 years
Terms: Studentship paying a stipend of around £13,726 p.a. and covering fees (£3,900 p.a).

Description

Applications are invited for a fully-funded PhD position within the Cellular and Molecular Neurosciences research group in the School of Pharmacy, University of Reading under the joint supervision of Dr Gary Stephens and Dr Ben Whalley. The project is jointly sponsored by an industrial partner, UCB Pharma and The School of Pharmacy.

This fully-funded 3-year studentship will use electrophysiological and immunological techniques to develop and investigate the functional effects of antibodies directed against intracellular domains on voltage-gated calcium ion channel proteins. Calcium channels play critical roles in many physiological processes in the central and peripheral nervous system and represent a major class of therapeutic targets. . The intracellular expression of antibody fragments (“intrabodies”) is a quite recent and highly innovating approach to specifically target and modulate proteins from the intracellular side and offers a great opportunity to design novel drug discovery tools. The successful student will receive training in electrophysiological (patch clamp recording) and cellular neuroscience techniques (including tissue culture, cell transfection) as well as in the development of monoclonal antibodies with the industrial partner, UCB. An important part of the project will involve the opportunity to undertake research placements with UCB, predominantly, but not restricted to, the first year of the project where research research activities will be run in the state-of-the-art discovery research environment at UCB (Slough). The successful candidate will also have the opportunity to attend national and international conferences to present results.

EU and UK candidates holding or expecting 1st class, 2(i) or equivalent degrees in appropriate subject areas are invited to apply for these studentships that are available after Oct 2013. Some prior experience with the systems and methods to be employed will be an advantage, but is not essential as full training will be given. Funding supports PhD stipend and bench fees, in addition to an allowance for conferences, travel, training and all direct project-related costs for UK/EU students.

School of Pharmacy, University of Reading
Dr G. J. Stephens: www.reading.ac.uk/pharmacy/about/staff/g-j-stephens.aspx
Dr B. J. Whalley: www.reading.ac.uk/pharmacy/about/staff/b-j-whalley.asp

Application process

Interested parties should address informal queries to Dr G. J. Stephens (g.j.stephens@reading.ac.uk). Applicants should submit a covering letter together with a current CV with details of 2 professional referees by email to Catherine Ashford, School of Pharmacy Research Secretary (c.ashford@reading.ac.uk)

The closing date for applications is Friday 12 July 2013.