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MRC Doctoral Training Programme Studentship, University of Glasgow, Glasgow, Scotland
Head of Pharmacology/Biology, Small molecule drug discovery company, Oxford, UK
Research Scientist, Inflammation Research, Pneumolabs, Harrow, UK
3 yr Post Doctorial Research Associate, UCL, London, UK
Project title: Suppression of IL-6 signalling by BMP4: a "missing link" in the development of pulmonary arterial hypertension?
Supervisors: Dr. Tim Palmer and Professor Mandy MacLean
Project Summary: Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature. Heritable PAH is associated with haploinsuffiency of the bone morphogenetic protein receptor II (BMPRII) leading to pulmonary vascular remodelling. Current therapeutic options simply relieve symptoms such as breathlessness, and so there is an urgent need to identify processes that could be targeted pharmacologically to arrest and/or reverse disease progression. Our original hypothesis is that one important consequence of defective BMP4/BMPR-II signalling is a reduced ability to inhibit IL-6-mediated trans-signalling in the pulmonary vasculature via induction of "suppressor of cytokine signaling 3" (SOCS3), and that this contributes to the chronic pulmonary inflammation observed in PAH. To test this hypothesis, the student will pursue an integrated programme of work that brings together the complimentary expertise of the two supervisors. This will involve A) Identifying the signalling pathways and transcription factors responsible for BMP4-mediated induction of SOCS3, B) Assessing IL-6 responses in pulmonary vascular cells from control and PAH patients, and C) Examining the translational potential of these findings using established in vivo models of PAH in mice in which IL-6 signalling complexes have been rendered resistant to inhibition by SOCS3.
Training: The project will provide opportunities for inter-disciplinary training in molecular cell biology and cutting edge technologies to examine cell signalling networks, as well providing training in cardiovascular physiology and in vivo whole animal research techniques. This will be supported by an extensive generic and transferable skills training programme provided by the College of Medical, Veterinary and Life Sciences Graduate School.
The studentship will be carried out within the Institute of Cardiovascular and Medical Sciences, which was recently designated as a BHF Centre of Excellence due to the outstanding training environment and opportunities for collaborative translational research.
Details: This is a fully funded 3.5-year PhD studentship commencing in October 2014. Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in Biochemistry, Pharmacology or a related subject. The financial package will include a 3.5 year stipend (currently £13,726 per annum), approved University fees, Research Training Support Grant and a conference allowance.
Interested students should contact Dr. Tim Palmer (Tim.Palmer@glasgow.ac.uk) for more information in the first instance.
An emerging and ambitious venture-capital backed biotechnology company, spun out from Oxford University and developing small molecule drug candidates, is looking to recruit an experienced person to provide scientific and managerial leadership to its on-going drug discovery programmes in the areas of in vitro pharmacology, in vivo pharmacology, and biomarker assessment. Candidates must have extensive experience of small molecule drug discovery and development in an industrial setting, and would ideally have previous experience of working on ion channel targets and/or in the area of inflammation/allergy. The role will involve supervising internal laboratory activities as well as significant collaborations with academic partners and commercial technical service provider companies. The successful candidate will provide strategic direction to the company’s discovery programmes and will provide key contributions to the broader leadership of the organisation.
The role is expected to be full time - with some flexibility, and a competitive compensation package will be available to the right senior, experienced scientist.
The company is located in the Oxford area.
Please reply, including a brief CV, to firstname.lastname@example.org.
Pneumolabs is a small preclinical research services company specialising in a wide range of tests/models of Respiratory Disease. We are based in North London where we have our own self-contained laboratories. We currently have vacancies for graduates in Pharmacology or an equivalent qualification. You will be part of a team, which interacts with Pharma at all levels so a good level of communication and self-motivation are necessary. You will be responsible for organising, running and analysing a range of tests/models of Inflammation with the main focus on Respiratory disease.
You must hold a BSc or MSc in a relevant biological science and be proficient in a range of IT skills.
As a member of the preclinical research service team, you will help to establish and run a wide range of tests or models of Inflammation. You will analyse and assist in the interpretation and reporting of client studies in conjunction with Senior Scientists in the team.
• Set up and run a range of tests/models under the supervision of Senior Research Scientists
• Analyse and assist in the interpretation and reporting of client studies
• Maintain an accurate record of all studies undertaken and data generated
• Assist in running an active suite of laboratories, monitoring and ordering consumables as required
• Actively participate in regular laboratory and strategic meetings
Required Qualifications - Education/Work Experience
• BSc in relevant biological science
• Previous experience of working in a laboratory environment with HO license desirable but not critical
• Excellent communication and organisational skills
• Strong IT skills
• Work with or without supervision
• A team player
To enquire further or apply, please send your CV and a covering e-mail to email@example.com.
The closing date for applications is 20 December2013.
To measure, in real time and invivo, 5-HT and glutamate release in the NTS
Duties and Responsibilities
Applications are invited for a Research Associate (postdoctoral) position to study the invivo the release if glutamate and 5-HT in the NTS. The successful applicant will combine electrophysiological, biosensor and voltammetric recordings and optical stimulation in in vivo preparations. The project is based in the laboratory of Professor Andrew G Ramage.
The position is funded by grant to study the "Role of 5-HT in the regulation of glutamate release from cardiovascular afferents in the nucleus tractus solitarius" from the BHF for 3 years and is available now.
• The successful applicant will have a PhD (or close to being awarded a PhD) in physiology, neuroscience or pharmacology and a proven track record in combining electrophysiological with neuropharmacology techniques, and a keen interest in understanding the mechanisms of transmitter release related to afferent input. A knowledge/experience of voltammetry, biosensor technology, optogenetics and using in vivo animal models would be useful.
Salary (inclusive of London allowance): £32,375 per annum spine point 29.
If you are interested please do not hesitate to contact Prof. Andy Ramage (firstname.lastname@example.org).
For further information and to apply for the post, please go to www.ucl.ac.uk/hr/jobs and search on reference 1384741 If you have any queries regarding the application process, please contact Jeremy Guyer, email@example.com.