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Lecturer in Pharmacology 

University of Reading, School of Pharmacy
Closing date: 9th Nov 2014
Post type: full-time, Permanent
Grade: 7 (Lecturer)

The University of Reading is building on its highly successful research reputation through the appointment of a new post as Lecturer in Pharmacology. In particular, we welcome applicants whose research complements our current research related to Cellular and Molecular Neuroscience, Cardiovascular Biology and/or Regenerative Medicine. Scientists working on in vivo models of disease or in related fields with implications for neural/cardiac function and therapeutics are particularly welcome. Applicants should demonstrate internationally competitive research expertise, and an appropriate track record of innovation in the field of pharmacology or a closely related discipline. The post holder will be based in the School of Pharmacy.

You will have:
•An excellent research track record in an appropriate field, as shown by publications and research funding, with experience of securing research funding that is commensurate with the post
•The research skills and experience to develop an independent, externally-funded research programme
•Research interests in pharmacology allied to either neuroscience, cardiovascular or regenerative medicine
•The desire to collaborate with other researchers across Pharmacy, Chemistry and Biomedical Sciences to develop new research opportunities
•A PhD in a relevant area with appropriate postdoctoral experience
•The desire and aptitude to contribute to pharmacology and therapeutics teaching to Pharmacy students
•The desire and aptitude to contribute to administrative duties within the Department

Informal contact details
Contact role: Director of Pharmacology &Therapeutics
Contact name: Professor Gary Stephens
Contact phone: +44(0)118 378 6156
Contact email: g.j.stephens@reading.ac.uk

Alternative informal contact details
Contact role: Head of the Reading School of Pharmacy
Contact name: Professor Helen Osborn
Contact phone: +44(0)118 378 7338
Contact email: h.m.i.osborn@reading.ac.uk

To formally apply please visit www.reading.ac.uk/jobs or contact Human Resources, University of Reading, Whiteknights, PO Box 217, Reading RG6 6AH. Telephone +44(0)118 378 6771 (voicemail)

Please quote the relevant reference number LE14041.

Head of Operations, Science Media Centre 

Salary: £40,000 - £45,000

Would you like to play an important role in improving the way science is covered in the news?

Ebola, statins, animal research, e-cigarettes, fracking, sugar....if it's in the news and about science the SMC will be working full time to proactively pump out the best, most accurate, evidence based science into the 24 hour news media.

But this frenetic media operation needs fuelling. It needs a highly competent, calm individual who makes everything run smoothly and who takes satisfaction from ensuring that the team of energetic, dynamic press officers can make a difference to science in the media every day.

The Head of Operations is a key member of the Senior Management Team. Responsible for the financial management, fundraising, preparation of annual accounts and bookkeeping you will have a clear head for numbers. You will provide the operational underpinning for the Centre ensuring the smooth running of IT, media briefings, events, contracts and all office systems. Acting as secretary to the Board of Trustees and Advisory Committee you will guide the governance of the charity and complete statutory reporting. Highly organised and efficient with the ability to work under pressure and multitask, you will need to remain focused on your role without being drawn into the other activities of the Centre. Not afraid to get your hands dirty, you will provide a lot of practical support as well as managing systems.

Read the role profile

For an informal discussion about the role please contact:

Selina Kermode, current post holder, 020 7611 8307 (unavailable 13-24 Oct)
Fiona Fox, Chief Executive, 020 7611 8365 (unavailable 27-31 Oct)

To apply please send a covering letter and CV to jobs@sciencemediacentre.org by 9am on Wed 5 November. Interviews will take place on Mon 17 Nov and Wed 19 Nov.

MRC PhD Studentship

Institute of Dentistry and The William Harvey Research Institute Barts and the London School of Medicine & Dentistry, Queen Mary University of London 

Academic supervisors: Professor Mike Curtis and Professor Amrita Ahluwalia

Project Title: Investigation of the Influence of Dietary Nitrate on the Oral Microbiome in Atherosclerosis

Applications are invited from graduates with a BSc (First or Upper Second) or MSc (Distinction or Merit). Previous research experience would be an advantage. This 3 year studentship will commence on 1st October 2015 and the applicant will be based in the School's Institute of Dentistry (http://www.dentistry.qmul.ac.uk) at Whitechapel and The William Harvey Research Institute (http://www.whri.qmul.ac.uk) at Charterhouse Square. This is an exciting opportunity for a graduate from disciplines related to microbiology and pharmacology.

Background:

Cardiovascular disease is the biggest cause of mortality worldwide underlying the rise in levels of non-communicable disease and recently recognized by the WHO as an urgent imperative for research focus and funding, with a view to identification of novel strategies preferably applicable to diverse global communities. This imperative has renewed interest in harnessing the beneficial effects of diets rich in fruit and vegetables. Of relevance to this proposal, green leafy vegetables provide the greatest protection against cardiovascular disease above all other fruit and vegetables. Importantly, this class of vegetable has naturally high inorganic nitrate (NO3 -) content and this nitrate has been shown to exert a host of beneficial effects upon the cardiovascular system. However, there has been little focus on the possibility that certain symbiotic oral bacteria might operate to promote cardiovascular health. We, and others, have shown that ingested nitrate in vivo undergoes sequential chemical reduction to nitrite followed by conversion of nitrite to NO that ultimately results in lowered blood pressure (BP) and improved vascular and platelet function. Importantly, the first step of the conversion of nitrate to nitrite is not a mammalian response but rather is dependent upon a symbiotic relationship between the host and commensal oral microbiota that has been dubbed the ‘enterosalivary circuit’. However, the exact nature and identity of the microbiota key to this circuit and whether it might be modified by diet are uncertain. PhD project hypothesis: manipulation of the nitrate-reducing microbiota, through dietary approaches, may exert beneficial effects on cardiovascular health. The aim of this PhD is to investigate the effects of long term dietary nitrate feeding on the oral microbiome and cardiovascular function in a model of atherosclerosis. We seek a motivated student with an interest in the microbiome and its impact on cardiovascular disease. The PhD project will offer the student experience of a range of exp[eriemntal methods techniques including a range of molecular biology techniques including second generation sequencing of bacterial communities, microbiological methods, biochemical methods of assessment of nitrate reductase activity and experimental models. The student will gain expertise in data handling, statistical analysis and manuscript preparation.

Informal Enquiries can be made to: Professor Curtis e-mail: m.a.curtis@qmul.ac.uk or Prof Ahluwalia : a.ahluwalia@qmul.ac.uk

This Studentship is funded by the MRC and comes with a tax-free stipend of approximately £18,500 per annum. It is open to UK Nationals, EEA/Swiss migrant workers and non-UK nationals with indefinite leave to remain in the UK who will have three years ordinary residence in the UK prior to the start of the studentship. University tuition fees (at UK/EU levels) will be met by the funding body.

Please refer to website for full eligibility details: http://www.mrc.ac.uk/skills-careers/studentships/studentship-guidance/studenteligibility- requirements/ To apply, please send a copy of your CV and a covering letter to the supervisor

Closing date: 7th November 2014 Interviews will be held on 5th December 2014.

Strathclyde Chancellor’s Fellowship 

Salary Range: £34,233 - £47,328
Closing Date: Monday, 27 October 2014

Through the Strathclyde Chancellor’s Fellowship Scheme we are seeking to appoint up to 20 exceptional early career academics in strategically important research areas. The Fellowships will normally be appointed at Lecturer level and will offer an academic career (“tenure track” equivalent) with the expectation that candidates will achieve promotion within the 5 year Fellowship period. Fellows who meet the criteria for promotion by the end of the 5 year period and continue to demonstrate a strategic fit in terms of research interests, will continue in an open-ended ("tenured" equivalent) academic appointment at the appropriate level. Exceptionally, where a candidate has an established track record in research leadership, appointments may initially be made at Senior Lecturer level with an expectation that promotion to Reader level will be attained within 5 years.

For further details and to apply go to: http://www.strathvacancies.co.uk/the-fellowship.html

PhD studentship in Pulmonary hypertension: Sex, drugs and ROCK and Rho 

PThis MRC funded programme provides students with cutting-edge research opportunities in medical research. Projects will align with MRC strategic priorities.

Project summary: This will bring together the Scottish Pulmonary Vascular Unit (www.spvu.co.uk) who are the only Scottish Clinical Centre for patients with Pulmonary Hypertension and the research group of Prof Mandy MacLean.

Pulmonary arterial hypertension (PAH) is a disease of the pulmonary vasculature resulting in right heart failure and death. PAH occurs more frequently in females compared to males but the reasons for this are unclear. PASMCs normally exhibit low rates of proliferation, migration, and apoptosis to maintain a low resistance pulmonary circulation. However alterations in signalling pathways can lead to abnormal proliferation, apoptosis and migration. In human pulmonary arterial smooth muscle cells (hPASMCs) the most important signalling pathway is the bone morphogenetic protein receptor type 2 (BMPR2) pathway. A mutation in the bone morphogenetic protein receptor type 2 (BMPR2) gene underpins heritable PAH (hPAH). MAP kinases also underpin proliferative responses in human pulmonary cells. We have recently identified basal differences in proliferative signalling between male and female hPASMCs. Compared with male hPASMCs, female cells have decreased BMPR2 signalling, increased pERK2, increased estrogen synthesis, increased estrogen metabolism, increased estrogen receptor alpha and increased proliferation to key mitogens including PDGF and serotonin.

This PhD will focus on unravelling the reasons behind these phenotypic differences in both hPASMCs and pulmonary fibroblasts and further investigation into the pERK/ROCK and Rho system which underpins serotonin-induced and oestrogen-induced proliferation in hPASMCs. We have characterised serotonin-dependent models of PH where only females develop PH and these will be studied to examine the effect of gender on these systems in vivo. For example the therapeutic effects of the ROCK inhibitor Fusadil will be studied in these models and in the sugen/hypoxic model (males and females). Pulmonary vs systemic differences will also be identified by comparing arterial SMCs derived from gluteal biopsies.

The student will learn in vivo skills such as in vivo (haemodynamic measurements, drug dosing and ovariectomy) in vitro and in situ expression studies, molecular biology and imaging. They will also be exposed to a clinical environment. Visit the website for more information. Deadline for applications is 28 November 2014.

General enquiries regarding the programme and application procedure should be directed to Alexis Merry.

MRC Integrative-Toxicology Training Partnership (ITTP)- Call for PhD Studentship Applications 

Five MRC ITTP 4-year studentships are available to start October 2015 funded by the MRC Toxicology Unit. Through partnerships between academia, industry and government the initiative seeks to build expertise in toxicology and related disciplines that is required to ensure the safe and effective development of drugs, chemicals and consumer products, and to provide better assessment of risk deriving from environmental exposure.

Applications should be submitted from potential academic supervisors with collaborative partners in industry, government agencies or other universities. Applicants are required to attend an Interactive meeting at the MRC Toxicology Unit, Leicester on the 22 September 2014 to discuss ideas. If unavailable a senior representative can attend. Potential research areas for discussion at the Interactive meeting are welcome in advance.

Research projects should meet the main aim of ITTP in achieving cross-fertilisation between toxicology and advances in other disciplines. The emphasis is on aligning modern cell and molecular biology with other fundamental and health-related disciplines to provide an integrative holistic approach in research and training relevant to predicting the toxicity of chemicals and drugs as well as to develop an understanding of the chemical, pharmacological and biological processes involved. The contributions of each partner should be clearly stated.

The proposed work should be feasible to be conducted by a PhD student and successfully submitted as a thesis within four years. A key feature of the initiative is its training programme which brings together aspects of established toxicology knowledge with other relevant sciences at an annual residential course.

Assessment criteria
Applications will be ranked ultimately by the ITTP Steering Committee. Decisions will be reached on the basis of scientific quality, feasibility, the integrative, multidisciplinary nature of proposed projects in line with the aims of ITTP and the likelihood of success. Key criteria for assessment will be:

• The novelty of the research proposal in the field of toxicology
• The relevance of the proposal in the light of present toxicological concerns for human health
• Proposals that span and use a variety of skills in in vivo and in vitro contexts
• The likelihood of the applicant providing the appropriate scientific environment and guidance to students.

How to apply
Application forms can be down loaded from the MRC Toxicology website, under the heading Integrated Toxicology Training Partnership  Enquiries, including registration for participation in the Interactive meeting, and completed application forms should be sent to Professor Andy Smith.

Deadline date
Deadline for the receipt of final applications will be 30 November 2014

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