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UCB PhD Research Scientist Roles: Molecular Biologist, Biochemist, Neuroscientist, Cellular Biologist, HCS Biologist
Tenure-Track Associate Professor/Full Professor Position in Pharmacokinetics
Lectureship in Biomedical Sciences
Educator Track Faculty Position
PhD studentship in Pulmonary hypertension: Sex, drugs and ROCK and Rho
Based at Braine l’Alleud, Belgium - 20 Km south of Brussels
UCB is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 8,500 people in more than 40 countries, the company generated revenue of €3.4 billion in 2012. UCB is listed on Euronext Brussels (symbol: UCB).
In order to further strengthen our New Meds team, we are looking for:
Please follow the links for more information about the positions and how to apply.
Deadline for applications is 6 December 2014
Applications are invited for a full-time tenure-track Associate Professor/Full Professor of Pharmacokinetics. The Faculty is continuing the development of its research priority in the field of pharmacokinetics. In particular, we wish to focus on the areas of physiologically-based pharmacokinetic modeling, pharmacokinetic-pharmacodynamic modeling, population-based modeling, the applications of these methodologies and concepts in drug discovery and development, the clinical use of therapeutic antibodies, and targeted personalized medicine. Specific areas of research expertise should lead to collaborations with both basic and clinical/practice researchers internal and external to the Faculty.
Applicants for this position should possess a Ph.D. degree or equivalent with a specific focus on basic and applied pharmacokinetics, relevant postdoctoral and/or industrial research experience, proven research skills, and an outstanding publication record. Excellent teaching and communication skills as well as a strong commitment to undergraduate, graduate and post-doctoral education are essential. An undergraduate degree in pharmacy is desirable, but not required. The appointee will be expected to successfully compete for national and international research funding (e.g., CIHR, NIH) as a principal investigator. Extensive expertise in the science of drug absorption, distribution, metabolism, and excretion, especially as it relates to biopharmaceutics at the cellular and/or whole organ level, is preferred. Relevant research experience in the pharmaceutical industry, including expertise in pharmacokinetic modeling, systems pharmacology, and the application of Simcyp, WinNonLin, and NONMEM software programs would be a distinct advantage. The applicant’s record of teaching, research/scholarly activity, and service must be at a level appropriate for appointment at the rank of Associate Professor or Full Professor at the University of British Columbia.
The major focus of this position will be the continued development of a world-class research program supported by extensive extramural funding. Other responsibilities will include teaching and training students in the B.Sc.(Pharm.), Pharm.D., and M.Sc./Ph.D. programs. The Faculty of Pharmaceutical Sciences is experiencing unprecedented growth and expansion, and is now located in a new state-of-the-art $133-million, 246,000-square-foot facility on UBC’s Vancouver campus underpinned by world-class infrastructure and equipment. The building also houses one of the Faculty’s key partners, the Centre for Drug Research and Development (www.cdrd.ca), and is within easy reach of other major health science faculties, core research facilities, and major clinical centres.
Salary is negotiable, commensurate with experience and subject to final budgetary approval.
The closing date for applications is 30 November 2014; preferred start date is July 1, 2015 or earlier.
Interested individuals are requested to submit a letter of application with a brief description of research interests, a curriculum vitae, copies of up to five publications, a statement of teaching philosophy, and the names of five referees to: Chair, Pharmacokinetics Search Committee Faculty of Pharmaceutical Sciences The University of British Columbia 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada Faculty Website.
Please submit electronic applications through the UBC Careers Website.
UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply. We especially welcome applications from visible minority groups, women, Aboriginal persons, persons with disabilities, persons of minority sexual orientations and gender identities, and others with the skills and knowledge to engage productively with diverse communities. Canadians and permanent residents of Canada will be given priority.
Location: Highfield Campus
Salary: £36,309 to £45,954
Full Time Permanent
Closing Date: Sunday 04 January 2015
The University of Southampton is one of the top 15 research intensive universities in the UK. To build on our education and research success to date, and as part of an exciting expansion programme in Biological Sciences (http://www.southampton.ac.uk/biosci) planned over the next 3 years and which has resulted in recruitment already this year, the Faculty of Natural and Environmental Sciences is inviting applications for a further academic position within the Centre for Biological Sciences.
We wish to appoint an outstanding person, whose research fits within the broad theme of biomedical sciences. Ideally your research will complement existing research strengths in cell and developmental biology, molecular biology, neuroscience, microbiology, cell signalling, or the molecular basis of disease, but all strong candidates are encouraged to apply. Our goals are to gain a better understanding of the fundamental properties of cells and systems, and apply this knowledge to physiological systems and disease states. It is necessary that you will have an established track record of research and be well positioned to attract RCUK, EU or biomedical charity funding. You will also be expected to make a major contribution to our Biomedical Sciences undergraduate programme, as well as being able to teach into one or more of our other programmes (Biology, Zoology, Pharmacology, and Biochemistry). It is especially important that you show enthusiasm and potential to teach innovatively across a wide range of disciplines. We would particularly encourage applicants who have the ability to teach mammalian and comparative physiology.
You will join the Centre for Biological Sciences, which is at the hub of interdisciplinary initiatives through its engagement with the Institute for Life Sciences (IfLS, http://www.southampton.ac.uk/ifls). You will be encouraged to pursue collaborative multidisciplinary research with other groups across the university, especially within the Faculty of Natural and Environmental Sciences (Chemistry, Ocean & Earth Science) or Faculty of Medicine.
You should demonstrate:
Potential applicants who wish to discuss this post are welcome to contact Professor Keith Jones (Head of Centre for Biological Sciences, K.T.Jones@soton.ac.uk).
Interviews are likely to take place in February 2015.
You should submit your completed application form online at www.jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Carol Read (Recruitment Team) on +44 (0) 23 8059 3649. Please quote reference 474914BJ on all correspondence.
National University of Singapore
DEPARTMENT OF PHARMACOLOGY
YONG LOO LIN SCHOOL OF MEDICINE
The National University of Singapore (NUS) Yong Loo Lin School of Medicine invites applications for one full-time Educator Track Faculty position (Lecturer / Senior Lecturer) in the Department of Pharmacology.
Qualifications and Requirements:
Candidates must hold a PhD or equivalent Degree, possess excellent communication skills, and be familiar with / have training and experience relevant to biomedical sciences. Candidates with established and wide-ranging teaching experience will be preferred.
The successful candidate is expected to carry a significant teaching load at undergraduate level to 5 major student groups:
v. Life Sciences
The candidate is expected to excel in teaching (lectures, small group tutorials, and practicals), contribute to new teaching initiatives, be involved in student supervision, consultation and assessments, as well as provide leadership in educational areas, including curriculum design, development of new materials, and e-learning.
Remuneration and level of appointment will commensurate with qualifications and experience. The contract for appointment is for a three-year term in the first instance, with renewal subject to performance.
Interested candidates should submit their applications with the following supporting documentation:
i. Cover letter
ii. A detailed CV
iii. Statement of teaching philosophy
iv. Evaluation on teaching from faculty members or students of current institution (if applicable)
v. Description of currently taught syllabus, highlighting specific teaching contribution
vi. 3 Reference letters
Closing date of application: 10 December 2014
Please send applications to:
Associate Professor W.S. Fred WONG
Head, Department of Pharmacology,
Yong Loo Lin School of Medicine,
National University of Singapore,
Clinical Research Centre, Blk MD11, #05-09,
10 Medical Drive, Singapore 117597
Fax: (65) 68737690
PThis MRC funded programme provides students with cutting-edge research opportunities in medical research. Projects will align with MRC strategic priorities.
Project summary: This will bring together the Scottish Pulmonary Vascular Unit (www.spvu.co.uk) who are the only Scottish Clinical Centre for patients with Pulmonary Hypertension and the research group of Prof Mandy MacLean.
Pulmonary arterial hypertension (PAH) is a disease of the pulmonary vasculature resulting in right heart failure and death. PAH occurs more frequently in females compared to males but the reasons for this are unclear. PASMCs normally exhibit low rates of proliferation, migration, and apoptosis to maintain a low resistance pulmonary circulation. However alterations in signalling pathways can lead to abnormal proliferation, apoptosis and migration. In human pulmonary arterial smooth muscle cells (hPASMCs) the most important signalling pathway is the bone morphogenetic protein receptor type 2 (BMPR2) pathway. A mutation in the bone morphogenetic protein receptor type 2 (BMPR2) gene underpins heritable PAH (hPAH). MAP kinases also underpin proliferative responses in human pulmonary cells. We have recently identified basal differences in proliferative signalling between male and female hPASMCs. Compared with male hPASMCs, female cells have decreased BMPR2 signalling, increased pERK2, increased estrogen synthesis, increased estrogen metabolism, increased estrogen receptor alpha and increased proliferation to key mitogens including PDGF and serotonin.
This PhD will focus on unravelling the reasons behind these phenotypic differences in both hPASMCs and pulmonary fibroblasts and further investigation into the pERK/ROCK and Rho system which underpins serotonin-induced and oestrogen-induced proliferation in hPASMCs. We have characterised serotonin-dependent models of PH where only females develop PH and these will be studied to examine the effect of gender on these systems in vivo. For example the therapeutic effects of the ROCK inhibitor Fusadil will be studied in these models and in the sugen/hypoxic model (males and females). Pulmonary vs systemic differences will also be identified by comparing arterial SMCs derived from gluteal biopsies.
The student will learn in vivo skills such as in vivo (haemodynamic measurements, drug dosing and ovariectomy) in vitro and in situ expression studies, molecular biology and imaging. They will also be exposed to a clinical environment. Visit the website for more information. Deadline for applications is 28 November 2014.
General enquiries regarding the programme and application procedure should be directed to Alexis Merry.