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Consultant in medicine and clinical toxicology, Edinburgh 

NHS Lothian is seeking to appoint a new consultant in medicine and clinical toxicology, based at the Royal Infirmary of Edinburgh, with the potential for research links to the University. We are keen that a clinical pharmacologist is appointed to join our team. Existing consultant staff within the Unit include Professors Michael Eddleston, Simon Maxwell and David Webb (Head of Unit), and Drs James Dear, Hafid Narayan, Euan Sandilands and Arvindan Veiraiah. Interests within the Unit focus on biomarkers, cardiovascular and renal disease, clinical toxicology and prescribing skills (Prescribe and PSA). There are currently three trainees, and there has been a history of linking clinical pharmacology to specialties beyond internal medicine (such as clinical oncology, general practice, infectious disease and renal medicine). There is a strong academic presence within the Unit, which host MRC and Wellcome Trust translational medicine programmes. 

The closing date for applications is 1 September and interviews will be held on 21 October 2014.

We encourage anyone interested in applying to have an informal discussion with Professor Michael Eddleston (07910-106484) or David Webb (07770-966786).

Lecturer in Pharmacology (2 Posts) 

University of East Anglia

An opportunity has arisen within the School of Pharmacy for two individuals to join the Pharmacology group. Researchers with experience and expertise in cell or molecular biology or pharmacology are invited to apply. A PhD in a relevant research area is an essential requirement as is the expectation that the individual will contribute to the School's next Research Excellence Framework submission. The post holders will be expected to undertake and lead on independent research, contribute to the enterprise and engagement activities, undertake administrative duties commensurate to the role, deliver a reasonable teaching load and supervise final year research projects.

These posts are available from 1 January 2015 on a full-time, indefinite basis.

Closing date: 12 noon Thursday 11 September 2014

Further Information: www.uea.ac.uk/hr/vacancies/academic/-/asset_publisher/h0n2rDvu3ug8/content/lecturer-in-pharmacology-2-posts-

Research Associate 

Reference: T2-80011191-01
Manchester Metropolitan University

The Faculty of Science and Engineering is a thriving community of over 5,000 students and staff with an outstanding record of achievement in teaching and research and well-established links with industry. Our expertise spans healthcare science, biology, chemistry and forensic science, environmental and geographical science, engineering, physics, computing, mathematics and digital technology. In the last ten years we have invested over £50 million in our state-of-the-art laboratories, workshops and learning spaces. We recruit from over 100 countries around the world and our student body represents a wide mix of social backgrounds and ethnic origins, enriching the learning and social experience.

The School of Healthcare Science provides a stimulating academic environment for its staff and students in the heart of Manchester. The School encourages excellence in scholarship and research and has invested heavily in infrastructure providing state of the art laboratory accommodation. Our new £3m building for the Healthcare Science Research Institute has specialist facilities for work on cell and molecular biology, nutrition, orthopaedics, cardiovascular science, tissue culture, bioengineering and the advanced study of physiology.

Role

This is an exciting opportunity for an enthusiastic postdoctoral research associate to undertake research in the field of Cardiovascular Science and Bioengineering. The project is a collaborative venture between MMU and Industrial partners and involves the development and optimisation of an in vitro human cardiac microvascular model using endothelial cells, smooth muscle cells, and cardiomyocytes, which will be cultured on 3D engineered scaffolds and maintained in a specially designed chamber. The model will be utilised for drug and nanoparticle toxicity testing. The project is cross-disciplinary involving Vascular, Cell and Molecular biology, and Bioengineering.

Ideal Candidate

The work will involve establishing conditions for cell culture of endothelial cells, smooth muscle cells and cardiomyocytes, and to develop a cardiovascular co-culture of all three cell types on 3D scaffolds, under flow conditions. Experience in cell culture will be essential. Additional experience in molecular biology and histological techniques will be desirable but not essential. With an ability to work independently using your own initiative, you will have excellent organisational and problem solving skills. You will take responsibility for leading the project, under the overall direction by the project co-ordinators. The post will be for 14 months in the first instance

Grade and Salary Band: Grade 8 (£33,242 to £38,511)

For an informal discussion regarding the requirements of the role please contact Dr. May Azzawi (m.azzawi@mmu.ac.uk)

Closing date: 28 August 2014

Post-doctoral Research Scientist – Physiologist in Vascular Biology. 

Novel pathway regulating vascular tone and blood pressure

World Class Research Institute

Not-for-profit Organisation

Close to public transport in Darlinghurst 

Up to 3 years, subject to funding

The Victor Chang Cardiac Research Institute, established in 1994, is recognised as an international centre of excellence in biomedical research with a focus on heart disease and cardiovascular biology. Employing 200 staff, the Institute conducts research into the prevention of heart disease and undertakes cutting edge research. 

We are seeking an enthusiastic post-doctoral scientist to join an international team and who wants to forge a career in vascular physiology in the laboratory of Professor Roland Stocker, who leads the Vascular Biology Division.

The project extends previous studies by Professor Stocker’s laboratory (Nat Med 2010;16:279; Crit Care Med 2011;39:2678) and aims at characterizing the mechanism underlying indolamine 2,3-dioxygenase-dependent regulation of vascular tone. The successful candidate will be highly motivated, have experience in vascular biology and will be sufficiently dynamic to move the project forward whilst working in a multi-disciplinary research team.

The successful applicant will hold a PhD in Physiology or related subject and have proven experience in wire and/or pressure myography. Experience with small animal handling and microsurgery is essential. Knowledge of cell and molecular techniques is desirable and familiarity with redox biology is an advantage.

Salary will commensurate with qualifications and experience. Salary packaging and superannuation options also apply.

Further information is available from Prof Roland Stocker (r.stocker@victorchang.edu.au).

Include a cover letter, current CV, proof of qualifications and details of three referees with your application. Email all applications to recruitment@victorchang.edu.au or apply online at our website.

Applications close Monday, 25 August 2014

Research Technician in Molecular Imaging 

Reference: FS0127
Campus: Hull
Faculty/Area: Faculty of Science and Engineering
Department: School of Biological, Biomedical and Environmental Sciences
Salary: £20,781 to £24,057 per annum Fixed Term Post
Type: Full Time

The School of Biological, Biomedical and Environmental Sciences at the University of Hull wishes to appoint a technician to join the imaging probe development team based in the recently completed Positron Emission Tomography (PET) Research Centre. This post will support all aspects of imaging in the PET Research Centre. This will include radiotracer handling, operation and QC of scanners and associated equipment, basic image analysis and routine laboratory management. The successful applicant will ideally have experience of preclinical imaging, however candidates with either an interest in or experience of working with oncology/cardiology models and/or nuclear imaging will be considered as extensive training will be provided.

The post is fixed term for one year. To discuss this role informally, please contact Dr Chris Cawthorne, T 01482 466776, E c.cawthorne@hull.ac.uk For information about the department visit www.hull.ac.uk/biology.

Closing date: Sunday 31 August 2014

MRC Integrative-Toxicology Training Partnership (ITTP)- Call for PhD Studentship Applications 

Five MRC ITTP 4-year studentships are available to start October 2015 funded by the MRC Toxicology Unit. Through partnerships between academia, industry and government the initiative seeks to build expertise in toxicology and related disciplines that is required to ensure the safe and effective development of drugs, chemicals and consumer products, and to provide better assessment of risk deriving from environmental exposure.

Applications should be submitted from potential academic supervisors with collaborative partners in industry, government agencies or other universities. Applicants are required to attend an Interactive meeting at the MRC Toxicology Unit, Leicester on the 22 September 2014 to discuss ideas. If unavailable a senior representative can attend. Potential research areas for discussion at the Interactive meeting are welcome in advance.

Research projects should meet the main aim of ITTP in achieving cross-fertilisation between toxicology and advances in other disciplines. The emphasis is on aligning modern cell and molecular biology with other fundamental and health-related disciplines to provide an integrative holistic approach in research and training relevant to predicting the toxicity of chemicals and drugs as well as to develop an understanding of the chemical, pharmacological and biological processes involved. The contributions of each partner should be clearly stated.

The proposed work should be feasible to be conducted by a PhD student and successfully submitted as a thesis within four years. A key feature of the initiative is its training programme which brings together aspects of established toxicology knowledge with other relevant sciences at an annual residential course.

Assessment criteria
Applications will be ranked ultimately by the ITTP Steering Committee. Decisions will be reached on the basis of scientific quality, feasibility, the integrative, multidisciplinary nature of proposed projects in line with the aims of ITTP and the likelihood of success. Key criteria for assessment will be:

• The novelty of the research proposal in the field of toxicology
• The relevance of the proposal in the light of present toxicological concerns for human health
• Proposals that span and use a variety of skills in in vivo and in vitro contexts
• The likelihood of the applicant providing the appropriate scientific environment and guidance to students.

How to apply
Application forms can be down loaded from the MRC Toxicology website, under the heading Integrated Toxicology Training Partnership  Enquiries, including registration for participation in the Interactive meeting, and completed application forms should be sent to Professor Andy Smith.

Deadline date
Deadline for the receipt of final applications will be 30 November 2014

Director, Translational Medicine & Clinical

Jim Gleeson at CK Clinical is recruiting for a Director, Translational Medicine & Clinical Pharmacology for a permanent position with a successful and dynamic international pharmaceutical company. The position will be based at their offices in the Home Counties.

Responsibilities: As the Director, Translational Medicine & Clinical Pharmacology your role will be to lead the early clinical development project team and to represent that team both internally and externally.

Specific duties will include:

  • Provision of strategic development direction and PK/PD, translational/biomarker and clinical expertise spanning late preclinical development through to Proof of Concept
  • Overseeing and contributing to the writing of early clinical development plans and target product profiles and work closely with other disciplinary teams to prepare documents such as the Clinical Trial Protocol, IMPD and Investigator Brochure
  • Leading the design of early phase clinical studies, review and analysis of study data and the preparation of final clinical study reports
  • Responsibility for budgetary management

Qualifications: As the Director, Translational Medicine & Clinical Pharmacology, you will require the following:

  • PhD in life sciences
  • Extensive early phase clinical research experience
  • Experience of clinical study design, writing clinical protocols and preparing regulatory submissions
  • An excellent knowledge of pharmacokinetic and pharmacodynamics principals
  • Line management experience
  • A background within oncology, cardiovascular or metabolic research would be advantageous

For more information or to apply for this Director, Translational Medicine & Clinical Pharmacology position please contact Jim Gleeson or call +44 (0)1438 842973. Alternatively please apply online now. CK Clinical is an Equal Opportunities employer and welcomes applications from all who meet our selection criteria. If you do not hear back from us within five working days of your application for this role, it means that on this occasion you have not been shortlisted for the next stage of the recruitment campaign.

Entitlement to work in the EEA is essential. Please quote reference CL28364 in all correspondence. 

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