British Journal of Pharmacology - Volume 155 Issue 5 (November 2008)

Showing 16 to 19 of 19 results

16. Behavioural and biochemical responses to morphine associated with its motivational properties are altered in adenosine A 2A receptor knockout mice

Date: Jan 29, 2009, Pages: 757-766

Background and purpose: The purinergic system through the A2A adenosine receptor regulates addiction induced by different drugs of abuse. The aim of the present study was to investigate the specific role of A2A adenosine receptors (A2ARs) in the behavioural and neurochemical responses to morphine associated with its motivational properties. Experimental approach: Mice...

17. Increase in hemokinin‐1 mRNA in the spinal cord during the early phase of a neuropathic pain state

Date: Jan 29, 2009, Pages: 767-774

Background and purpose: Substance P (SP), a representative member of the tachykinin family, is involved in nociception under physiological and pathological conditions. Recently, hemokinin‐1 (HK‐1) was identified as a new member of this family. Although HK‐1 acts on NK1 tachykinin receptors that are thought to be innate for SP, the roles of HK‐1 in neuropathic pain are still unknown. ...

18. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non‐cannabinoid receptor‐mediated mechanisms

Date: Jan 29, 2009, Pages: 775-782

Background and purpose: Tetrazoles were recently developed as inhibitors of the cellular uptake of the endocannabinoid anandamide or of its hydrolysis by fatty acid amide hydrolase (FAAH), but were proposed to act also on non‐endocannabinoid‐related serine hydrolases. Experimental approach: We tested, in a model of inflammatory pain induced in mice by formalin, five...

19. The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat α1β2γ2L GABA A receptor

Date: Jan 29, 2009, Pages: 783-794

Background and purpose: Fipronil is the active ingredient in a number of widely used insecticides. Human exposure to fipronil leads to symptoms (headache, nausea and seizures) typically associated with the antagonism of GABAA receptors in the brain. In this study, we have examined the modulation of the common brain GABAA receptor subtype by fipronil and its major metabolite, fipronil sulphone. ...

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